吲哚拉明——复极时间延长，人类心动过缓的一种机制？
Indoramin-prolongation of repolarization time, a mechanism of bradycardia in man?
作者信息
Harron D W, Nicholls D P, Shanks R G
出版信息
Br J Clin Pharmacol. 1985 Feb;19(2):266-71. doi: 10.1111/j.1365-2125.1985.tb02642.x.
Abstract
The effect of indoramin, a selective alpha 1-adrenoceptor antagonist, on ECG time intervals in normal man was studied. Significant prolongation of QTc was observed after indoramin 100 mg, with no change in QRS duration. In addition, the slope of the RR/QT relationship was changed by indoramin 100 mg. These results suggest that indoramin may have Class III antiarrhythmic activity. If such activity were to affect the SA node, it may explain at least in part the observed lack of reflex tachycardia after indoramin administration.
摘要
研究了选择性α1肾上腺素能受体拮抗剂吲哚拉明对正常人心电图时间间期的影响。服用100mg吲哚拉明后观察到QTc显著延长，QRS时限无变化。此外，100mg吲哚拉明改变了RR/QT关系的斜率。这些结果表明吲哚拉明可能具有Ⅲ类抗心律失常活性。如果这种活性影响窦房结，这至少可以部分解释服用吲哚拉明后未观察到反射性心动过速的现象。
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