Lv Xiaolong, Yang Lei, Xie Yunbo, Momeni Mohammad Reza
Department of Cardiothoracic Surgery, The People's Hospital of Changshou, Chongqing, China.
Department of Cardiothoracic Surgery, The People's Hospital of Tongliang District, Chongqing, China.
Front Cell Dev Biol. 2024 May 27;12:1397788. doi: 10.3389/fcell.2024.1397788. eCollection 2024.
Lung cancer is the second most common form of cancer worldwide Research points to the pivotal role of non-coding RNAs (ncRNAs) in controlling and managing the pathology by controlling essential pathways. ncRNAs have all been identified as being either up- or downregulated among individuals suffering from lung cancer thus hinting that they may play a role in either promoting or suppressing the spread of the disease. Several ncRNAs could be effective non-invasive biomarkers to diagnose or even serve as effective treatment options for those with lung cancer, and several molecules have emerged as potential targets of interest. Given that ncRNAs are contained in exosomes and are implicated in the development and progression of the malady. Herein, we have summarized the role of ncRNAs in lung cancer. Moreover, we highlight the role of exosomal ncRNAs in lung cancer.
肺癌是全球第二常见的癌症形式。研究表明,非编码RNA(ncRNAs)在通过控制关键途径来控制和管理病理学方面起着关键作用。在肺癌患者中,所有ncRNAs都被鉴定为上调或下调,这表明它们可能在促进或抑制疾病传播中发挥作用。几种ncRNAs可能是有效的非侵入性生物标志物,可用于诊断肺癌,甚至作为肺癌患者的有效治疗选择,并且有几种分子已成为潜在的感兴趣靶点。鉴于ncRNAs存在于外泌体中,并与该疾病的发生和发展有关。在此,我们总结了ncRNAs在肺癌中的作用。此外,我们强调了外泌体ncRNAs在肺癌中的作用。