两例具有快速进展性间质性肺病的抗MDA - 5皮肌炎的挑战性病例。
Two challenging cases of anti-MDA-5 dermatomyositis with rapidly progressive interstitial lung disease.
作者信息
Biddle Kathryn, Agaoglu Elif, Brent Geoffrey, Adam John, Nockels Rachel, Loveridge Adam, Bazari Farid, Natkunarajah Janakan, Al-Shakarchi Israa
机构信息
St George's University of London, Infection and Immunity, Cranmer Terrace, London, SW17 0RE, UK.
Kingston Hospital NHS Foundation Trust, Rheumatology, Kingston upon Thames, KT2 7QB, UK.
出版信息
Oxf Med Case Reports. 2024 Jun 7;2024(6):omae061. doi: 10.1093/omcr/omae061. eCollection 2024 Jun.
Anti-MDA-5 dermatomyositis (DM) is a subtype of idiopathic inflammatory myopathy, commonly presenting as clinically amyopathic dermatomyositis. It is associated with rapidly progressive interstitial lung disease and a poor prognosis. Here, we present two cases of anti-MDA-5 DM and discuss the challenges associated with timely diagnosis, and the importance of early and aggressive treatment.
抗黑色素瘤分化相关基因5（MDA-5）皮肌炎（DM）是特发性炎性肌病的一种亚型，通常表现为临床无肌病性皮肌炎。它与快速进展的间质性肺疾病及不良预后相关。在此，我们报告两例抗MDA-5 DM病例，并讨论及时诊断所面临的挑战以及早期积极治疗的重要性。
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