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颅内孤立性纤维瘤:一例21岁伴有幻嗅的男性病例

Intracranial Solitary Fibrous Tumor: A Case of a 21-Year-Old Male With Olfactory Hallucination.

作者信息

Rudolph Jackson E, Grice Guerard P, Lawless Michael H

机构信息

Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA.

Neuropathology, Naval Medical Center San Diego, San Diego, USA.

出版信息

Cureus. 2024 May 11;16(5):e60104. doi: 10.7759/cureus.60104. eCollection 2024 May.

Abstract

Meningeal solitary fibrous tumors (SFTs) are a rare central nervous system neoplastic process, resulting in frequent misdiagnosis as meningioma prior to pathologic analysis. Appropriate diagnosis is essential to lowering morbidity and mortality, as Grade II or III SFTs are aggressive neoplasms that possess metastatic potential. The existing data may suggest that intracranial SFTs primarily afflict those in their fourth through sixth decades of life. However, we present the case of a patient outside this demographic presenting with symptoms that we were unable to identify in any prior reports. A 21-year-old male in the United States Navy presented to the emergency department (ED) with a two-month history of progressive headaches, leading to nausea and emesis. The patient also endorsed a daily incidence of the same olfactory hallucination followed by several minutes of palpitations, flushing, and dizziness. His neurologic exam was unremarkable, but imaging in the ED revealed a large mass abutting the right medial sphenoid wing. The radiographic appearance of the mass with a dural tail led to a preoperative diagnosis of meningioma. However, pathologic analysis following gross total resection identified the mass as an SFT. A brief literature review complementary to this case underscored the high variability of intracranial SFT case presentations with a relative scarcity of epidemiologic data due to rarity. This review identified that it was common to initially diagnose SFTs as meningioma, similar to this particular case. This emphasizes the importance of an appropriate pathologic diagnosis. This case adds to the existing literature as anecdotal evidence of SFT occurring in a young patient and a unique symptom profile most notable for olfactory hallucination and dysautonomia as features of focal seizure.

摘要

脑膜孤立性纤维瘤(SFTs)是一种罕见的中枢神经系统肿瘤性病变,在病理分析之前常被误诊为脑膜瘤。正确诊断对于降低发病率和死亡率至关重要,因为II级或III级SFTs是具有转移潜能的侵袭性肿瘤。现有数据可能表明,颅内SFTs主要影响40至60岁的人群。然而,我们报告了一例该年龄段以外的患者,其症状在之前的任何报告中均未被发现。一名21岁的美国海军男性因进行性头痛两个月就诊于急诊科,头痛导致恶心和呕吐。患者还称每天都会出现相同的幻嗅,随后伴有几分钟的心悸、脸红和头晕。他的神经系统检查无异常,但急诊科的影像学检查显示右侧蝶骨嵴内侧有一个大肿块。肿块伴有硬膜尾征的影像学表现导致术前诊断为脑膜瘤。然而,全切除术后的病理分析确定该肿块为SFT。结合该病例进行的简短文献综述强调,颅内SFT病例表现高度多变,且由于罕见,流行病学数据相对匮乏。该综述发现,最初将SFTs诊断为脑膜瘤很常见,与该特定病例类似。这强调了正确病理诊断的重要性。该病例作为SFT发生在年轻患者中的轶事证据以及以幻嗅和自主神经功能障碍作为局灶性癫痫特征的独特症状表现补充了现有文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/11163863/0ff2302ced89/cureus-0016-00000060104-i01.jpg

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