[Ti]Ti-DOTA 配合物的合成与稳定性：迈向含氮大环 Ti 放射性药物。
Synthesis and stability of the [Ti]Ti-DOTA complex: en route towards aza-macrocyclic Ti-based radiopharmaceuticals.
机构信息
Department of Chemistry, University of Bergen, Allégaten 41, Bergen, Norway.
Department of Radiology, Haukeland University Hospital, Centre for Nuclear Medicine and PET, Jonas Lies vei 65, Bergen, Norway.
出版信息
Chem Commun (Camb). 2024 Jul 9;60(56):7148-7151. doi: 10.1039/d4cc01800a.
PMID:38860653
Abstract
We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with Ti, a guaiacol-based liquid-liquid extraction method, leads to a high radiochemical conversion up to 98%.
摘要
我们报告了 DOTA 作为钛螯合剂的用途。所得配合物得到了充分的表征，稳定性研究表明其具有很高的动力学惰性，不易发生转金属和转螯合反应。用 Ti 通过基于愈创木酚的液-液萃取方法对 DOTA 进行放射性标记，可获得高达 98%的高放射化学转化率。
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