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Roux-en-Y 胃旁路术后胆汁反流的再次减重手术:单中心长期队列研究。

Revisional Bariatric Surgery After Roux-en-Y Gastric Bypass for Bile Reflux: a Single-Center Long-Term Cohort Study.

机构信息

Metabolic and Abdominal Wall Reconstructive Surgery, Department of Surgery, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.

Department of General, Oncological, Metabolic and Thoracic Surgery, Military Institute of Medicine, National Research Institute, 04-141, Warsaw, Poland.

出版信息

Obes Surg. 2024 Jul;34(7):2420-2430. doi: 10.1007/s11695-024-07355-6. Epub 2024 Jun 11.

Abstract

PURPOSE

Revisional bariatric surgery (RBS) after primary Roux-en-Y gastric bypass (RYGB) is indicated for the efficient management of specific complications such as bile reflux. Published literature on this topic remains scarce as we aim to evaluate the long-term outcomes (10 years) of RBS for bile reflux after RYGB.

MATERIAL AND METHODS

We conducted a single-center retrospective study of patients who underwent primary RYGB complicated by bile reflux and had RBS between 2008 and 2023. Our cohort was divided into two groups based on the etiology of bile reflux. Long-term surgical outcomes and nutritional status were reported and compared between the groups.

RESULTS

A total of 41 patients (100% primary RYGB; 90.2% female, 97.6% white) were included. 56.1% (n = 23) of patients underwent Roux limb lengthening and the remaining 43.9% (n = 18) had a gastrogastric fistula takedown, with no significant differences in terms of intraoperative complications, estimated blood loss (p = 0.616), length of hospital stay (p = 0.099), and postoperative complications between the two groups. Long-term resolution of obesity-related medical conditions was demonstrated for all the evaluated comorbidities. Lastly, there was no reported mortality, bile reflux recurrence, or micro- and macro-nutrient deficiencies over the total follow-up period of 10 years.

CONCLUSION

In our cohort, RBS after a primary RYGB for bile reflux management demonstrated safe and efficient short- and long-term surgical outcomes without any reported bile reflux recurrence or mortality. Adequate supplementation and close patient follow-up remain essential to decrease the morbidity and mortality associated with RBS as further studies are required to support our findings.

摘要

目的

胃旁路术后再手术(RBS)是治疗原发性 Roux-en-Y 胃旁路术(RYGB)后特定并发症(如胆汁反流)的有效方法。目前,关于该主题的文献仍然很少,因此我们旨在评估 RYGB 后胆汁反流行 RBS 的长期结果(10 年)。

材料和方法

我们对 2008 年至 2023 年期间因胆汁反流而行 RYGB 后接受 RBS 的患者进行了单中心回顾性研究。根据胆汁反流的病因将我们的队列分为两组。报告并比较了两组的长期手术结果和营养状况。

结果

共纳入 41 例患者(100%为原发性 RYGB;90.2%为女性,97.6%为白人)。56.1%(n=23)的患者行 Roux 支延长术,其余 43.9%(n=18)行胃胃吻合口关闭术,两组在术中并发症、估计失血量(p=0.616)、住院时间(p=0.099)和术后并发症方面无显著差异。所有评估的合并症的肥胖相关医疗状况均得到长期缓解。最后,在 10 年的总随访期内,没有报告死亡率、胆汁反流复发或微量和宏量营养素缺乏。

结论

在我们的队列中,原发性 RYGB 后行 RBS 治疗胆汁反流的短期和长期手术结果安全且有效,没有报告胆汁反流复发或死亡率。充分的补充和密切的患者随访仍然是降低与 RBS 相关的发病率和死亡率的关键,需要进一步的研究来支持我们的发现。

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