Department of Surgery, Division of Trauma, Surgical Critical Care, Burns and Acute Care Surgery, Banner University of Arizona/University Medical Center, Tucson, AZ.
Department of Surgery, Division of Trauma Surgery/Surgical Critical Care, University of Texas Health Science Center, UT Health East Texas, Tyler, TX.
Wounds. 2024 May;36(5):148-153. doi: 10.25270/wnds/21122.
The use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been shown to be effective in removing nonviable tissue, reducing bioburden, and promoting granulation tissue formation in acute and chronic infected wounds.
To illustrate the clinical efficacy of the use of pure hypochlorous acid (pHA) antimicrobially preserved wound cleansing solution as the instillation fluid for NPWTi-d (NPWTi-d/pHA) in wound bed preparation in patients with complex wounds.
The treatment protocol for use of NPWTi-d/pHA in preparing wound beds for final closure is demonstrated in 3 illustrative cases of patients with complex wounds resulting from necrotizing infection and trauma with heavy contamination. All 3 patients developed a healthy-appearing wound bed deemed suitable for primary closure an average of approximately 1 month following initial surgical debridement.
The cases presented demonstrate the ability of a pHA antimicrobially preserved wound cleansing solution used as the instillation fluid with NPWTi-d to aid in bacterial reduction, mechanical debridement, and promotion of wound healing. Use of NPWTi-d/pHA in these cases of extensive necrotizing infection and posttraumatic injury with heavy contamination allowed for final closure an average of 1 month after initial surgical debridement.
负压伤口治疗联合冲洗和驻留时间（NPWTi-d）已被证明可有效清除失活组织、降低生物负荷并促进急慢性感染伤口肉芽组织形成。
说明在准备复杂伤口的床面时，将纯次氯酸（pHA）抗菌保存伤口清洗液作为 NPWTi-d（NPWTi-d/pHA）冲洗液的临床疗效，该冲洗液用于 NPWTi-d。
展示使用 NPWTi-d/pHA 准备最终闭合床面的治疗方案，该方案用于 3 例因坏死感染和严重污染创伤导致的复杂伤口患者。所有 3 例患者在最初的清创术后大约 1 个月后，均出现了健康的床面，适合进行一期闭合。
所提出的病例表明，使用 NPWTi-d 冲洗时，pHA 抗菌保存伤口清洗液作为冲洗液，可辅助减少细菌、机械清创并促进伤口愈合。在这些广泛坏死感染和创伤后严重污染的病例中使用 NPWTi-d/pHA，可在最初清创术后大约 1 个月进行最终闭合。
