Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Pharmacol Res. 2024 Jul;205:107255. doi: 10.1016/j.phrs.2024.107255. Epub 2024 Jun 9.
Research has shown that a significant portion of cancer patients experience depressive symptoms, often accompanied by neuroendocrine hormone imbalances. Depression is frequently associated with decreased levels of serotonin with the alternate name 5-hydroxytryptamine (5-HT), leading to the common use of selective serotonin reuptake inhibitors (SSRIs) as antidepressants. However, the role of serotonin in tumor regulation remains unclear, with its expression levels displaying varied effects across different types of tumors. Tumor initiation and progression are closely intertwined with the immune function of the human body. Neuroimmunity, as an interdisciplinary subject, has played a unique role in the study of the relationship between psychosocial factors and tumors and their mechanisms in recent years. This article offers a comprehensive review of serotonin's regulatory roles in tumor onset and progression, as well as its impacts on immune cells in the tumor microenvironment. The aim is to stimulate further interdisciplinary research and discover novel targets for tumor treatment.
研究表明，相当一部分癌症患者会出现抑郁症状，常伴有神经内分泌激素失衡。抑郁症常伴随着血清素（又被称为 5-羟色胺，5-HT）水平降低，因此通常使用选择性 5-羟色胺再摄取抑制剂（SSRIs）作为抗抑郁药。然而，血清素在肿瘤调控中的作用尚不清楚，其表达水平在不同类型的肿瘤中表现出不同的效果。肿瘤的发生和发展与人体的免疫功能密切相关。神经免疫作为一门交叉学科，近年来在研究心理社会因素与肿瘤及其机制的关系方面发挥了独特的作用。本文全面综述了血清素在肿瘤发生和发展中的调节作用，以及其对肿瘤微环境中免疫细胞的影响。目的是激发进一步的跨学科研究，发现肿瘤治疗的新靶点。
