Departamento de Pediatría e Infectología, Universidad Autónoma de Baja California, Baja California, Ensenada.
Servicio de Infectología, Hospital Infantil de México Federico Gómez, Ciudad de México.
Cir Cir. 2024;92(3):298-306. doi: 10.24875/CIRU.23000080.
To evaluate if the comorbidity and coinfections presented by SARS-CoV-2 infection vs. COVID-19 impact our Mexican children.
Prospective and observational study that included the 2020-2021 peak influenza season. All patients with a diagnosis of infection by SARS-CoV-2 vs. COVID-19 who were admitted to the Hospital Infantil de Mexico were analyzed. Real-time RT-PCR for SARS-CoV-2 was performed in all patients, determining E, RdRp and RP genes and protein N, as well as RT-PCR for detection of respiratory viruses.
The inclusion criteria were met by 163 patients. The group with the highest risk of becoming ill was adolescents (40.4%), followed by schoolchildren and preschoolers (21.4% and 19.6% of the cases, respectively). There were three cases with viral coinfection: two (1.2%) with parvovirus B-19 and one (0.6%) with herpes type I; another two (1.2%) showed bacterial coinfection. The main comorbidity were obesity, acute lymphoblastic leukemia and arterial hypertension. Regarding mortality, we only had four cases (2.4%).
Obesity, cancer, hypertension, heart disease and diabetes are comorbidity present in our patients, as referred to in literature, but not coinfections. In our study, we did not have any associated mortality related to comorbidity.
评估 SARS-CoV-2 感染与 COVID-19 引起的合并症和合并感染是否对墨西哥儿童产生影响。
这是一项前瞻性观察研究，纳入了 2020-2021 年流感高发季。分析了所有因 SARS-CoV-2 感染而住院的儿童患者。对所有患者进行实时 RT-PCR 检测 SARS-CoV-2，以确定 E、RdRp 和 RP 基因和蛋白 N，以及检测呼吸道病毒的 RT-PCR。
符合纳入标准的患者有 163 例。发病风险最高的是青少年（40.4%），其次是学龄儿童和学龄前儿童（分别占病例的 21.4%和 19.6%）。有 3 例合并病毒感染：2 例（1.2%）为细小病毒 B19，1 例（0.6%）为 I 型单纯疱疹病毒；另有 2 例（1.2%）合并细菌感染。主要的合并症是肥胖、急性淋巴细胞白血病和高血压。关于死亡率，我们只有 4 例（2.4%）。
肥胖、癌症、高血压、心脏病和糖尿病是我们患者存在的合并症，与文献报道的一致，但没有合并感染。在我们的研究中，没有任何与合并症相关的死亡。
