Department of Physiology and Pharmacology, Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
Learn Mem. 2024 Jun 11;31(5). doi: 10.1101/lm.053825.123. Print 2024 May.
To survive in changing environments, animals need to learn to associate specific sensory stimuli with positive or negative valence. How do they form stimulus-specific memories to distinguish between positively/negatively associated stimuli and other irrelevant stimuli? Solving this task is one of the functions of the mushroom body, the associative memory center in insect brains. Here we summarize recent work on sensory encoding and memory in the mushroom body, highlighting general principles such as pattern separation, sparse coding, noise and variability, coincidence detection, and spatially localized neuromodulation, and placing the mushroom body in comparative perspective with mammalian memory systems.
为了在不断变化的环境中生存，动物需要学会将特定的感觉刺激与正性或负性效价联系起来。它们如何形成刺激特异性记忆，以区分正/负相关刺激和其他不相关刺激？解决这个任务是昆虫大脑中关联记忆中心——蘑菇体的功能之一。在这里，我们总结了蘑菇体在感觉编码和记忆方面的最新工作，强调了模式分离、稀疏编码、噪声和可变性、一致性检测以及空间局部神经调制等一般原则，并将蘑菇体与哺乳动物记忆系统进行了比较。
