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结直肠手术后预防性输尿管支架置入致急性肾损伤

Acute kidney injury after colorectal surgery with prophylactic ureteral stents.

机构信息

Bayhealth Medical Center, 640 South State Street, Dover, 19901, DE, USA.

出版信息

Surg Endosc. 2024 Aug;38(8):4245-4250. doi: 10.1007/s00464-024-10941-5. Epub 2024 Jun 11.

Abstract

BACKGROUND

After colorectal surgery, acute kidney injury (AKI) results from a complex interplay of multiple independent causes and preventive measures that occur during the hospitalization. Prophylactic stenting for ureter identification has been identified as a potential cause, but the evidence is conflicting, possibly because of differing baseline characteristics and procedure-related approaches.

OBJECTIVE

This retrospective cohort study assesses the role of stents in the etiology of AKI after determining the independent predictors of AKI.

METHODS

From a population of 1224 consecutive colorectal patients (from 8/1/2016 through 12/31/2021), 382 (31.2%) received ureteral stents, and propensity score matching was used to create stented and control groups. Emergent cases and patients with sepsis were excluded from the analysis. Previously identified independent predictors of AKI, minimally invasive procedures, and a history of diabetes mellitus were used as criteria to create two balanced groups.

RESULTS

Baseline demographic characteristics and procedure-related factors baseline factors were similar between the groups. There was no difference in the rate of AKI between stented patients and controls (P = 0.82), nor was there any difference in postoperative complications, such as chronic renal insufficiency (CRI, P = 0.49), average postoperative creatinine (P = 0.67), urinary tract infections (UTI, P = 0.82), any postoperative infection (P = 0.48), in-hospital complications (P = 1.00), length of stay (LOS, P = 0.15), and 30-day readmissions (P = 0.79).

CONCLUSIONS

In a population of patients where stenting was frequently employed, ureter stents placed for identification did not appear to cause AKI or AKI-related complications.

摘要

背景

结直肠手术后,急性肾损伤(AKI)是由多种独立病因相互作用引起的,预防措施发生在住院期间。预防性输尿管支架置入术已被确定为潜在病因,但证据存在争议,这可能是由于基线特征和手术相关方法的不同。

目的

本回顾性队列研究通过确定 AKI 的独立预测因素,评估支架在 AKI 病因学中的作用。

方法

从 2016 年 8 月 1 日至 2021 年 12 月 31 日连续收治的 1224 例结直肠患者中,382 例(31.2%)接受了输尿管支架置入术,并进行了倾向评分匹配以创建支架组和对照组。排除急诊病例和脓毒症患者。采用 AKI 的独立预测因素、微创手术和糖尿病史等指标作为标准,创建两组均衡的队列。

结果

两组患者的基线人口统计学特征和手术相关因素无差异。支架组和对照组 AKI 发生率无差异(P=0.82),术后并发症如慢性肾功能不全(CRI,P=0.49)、平均术后肌酐(P=0.67)、尿路感染(UTI,P=0.82)、任何术后感染(P=0.48)、住院并发症(P=1.00)、住院时间(P=0.15)和 30 天再入院率(P=0.79)均无差异。

结论

在支架置入术广泛应用的患者人群中,为识别目的而放置的输尿管支架似乎不会导致 AKI 或 AKI 相关并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/11289140/be037a338533/464_2024_10941_Fig1_HTML.jpg

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