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医源性输尿管损伤与预防性支架在接受结直肠手术的退伍军人中的应用。

Iatrogenic Ureteral Injury and Prophylactic Stent Use in Veterans Undergoing Colorectal Surgery.

机构信息

Michael and Marian Ilitch Department of Surgery, Wayne State University School of Medicine / Detroit Medical Center, Detroit, Michigan; John D. Dingell VA Medical Center, Detroit, Michigan.

Michael and Marian Ilitch Department of Surgery, Wayne State University School of Medicine / Detroit Medical Center, Detroit, Michigan.

出版信息

J Surg Res. 2021 Sep;265:272-277. doi: 10.1016/j.jss.2021.03.054. Epub 2021 May 5.

Abstract

INTRODUCTION

Iatrogenic ureteral injury (IUI) is an uncommon complication in colorectal surgery. Prophylactic ureteral stenting (PUS) gained acceptance to aid in intraoperative identification of the ureter. Despite its use, the benefit of pus to avoid IUI remains debatable. We sought to analyze the rates of IUI after colorectal surgery in veterans and to compare the outcomes after PUS using a large matched cohort.

METHODS

The veterans affairs surgical quality improvement program database was queried for patients who underwent colorectal surgery from 2008-2015. To analyze the outcomes of PUS, we created two matched groups using propensity-score matching accounting for demographical and clinical cofactors to assess variable outcomes. Cross-tabulation was used to calculate rates of IUI and univariate and multivariate analyses were performed to evaluate risk factors associated with IUI.

RESULTS

27,448 patients were identified and 458 underwent PUS placement (1.6%). The majority of procedures were performed electively and with an open approach. Mean age was 65 y, 96.3% were male, and colorectal cancer was the most common indication. 45 patients (0.2%) were diagnosed with IUI. IUI incidence was higher in female patients, after left-sided colorectal resection, and in those undergoing open procedures. After matching, PUS use was associated with longer length of stay and operative time and increased creatinine levels from baseline.

CONCLUSION

We demonstrated that the use of PUS is independently associated with increased operative time and change in creatinine levels. Although no IUI occurred in the PUS group, this finding was not statistically significant. The risk and/or benefit ratio of PUS should be considered for each individual case, with its selective use based on the presence of risk factors for IUI, such as female patients and left-sided resections.

摘要

简介

医源性输尿管损伤(IUI)是结直肠手术中一种罕见的并发症。预防性输尿管支架置入术(PUS)已被广泛接受,有助于术中识别输尿管。尽管已经使用,但 PUS 避免 IUI 的益处仍存在争议。我们旨在分析退伍军人结直肠手术后 IUI 的发生率,并使用大型匹配队列比较 PUS 后的结果。

方法

从 2008 年至 2015 年,退伍军人事务部手术质量改进计划数据库中查询接受结直肠手术的患者。为了分析 PUS 的结果,我们使用倾向评分匹配创建了两组匹配,考虑了人口统计学和临床相关因素,以评估变量结果。交叉表用于计算 IUI 的发生率,单变量和多变量分析用于评估与 IUI 相关的危险因素。

结果

共确定了 27448 名患者,其中 458 名患者接受了 PUS 放置术(1.6%)。大多数手术是选择性的,采用开放性方法进行。平均年龄为 65 岁,96.3%为男性,最常见的适应症是结直肠癌。45 名患者(0.2%)被诊断为 IUI。女性患者、左侧结直肠切除术后以及开放性手术中 IUI 的发生率较高。匹配后,PUS 的使用与较长的住院时间和手术时间以及基线时肌酐水平的变化相关。

结论

我们表明,PUS 的使用与手术时间延长和肌酐水平变化独立相关。尽管 PUS 组没有发生 IUI,但这一发现没有统计学意义。应根据 IUI 的危险因素(如女性患者和左侧切除术),考虑每个患者的 PUS 的风险/获益比,并选择性地使用。

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