髋部骨折老年女性的肌肉和皮下脂肪组织大小、密度与股骨近端骨的关系。
Relationship between muscle and subcutaneous adipose tissue size and density and proximal femur bone in elderly women with hip fracture.
机构信息
Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
National Center for Orthopaedics, Shanghai Sixth People's Hospital, Shanghai, 200233, China.
出版信息
Aging Clin Exp Res. 2024 Jun 11;36(1):130. doi: 10.1007/s40520-024-02782-y.
BACKGROUND
Both osteoporosis and sarcopenia are associated with aging, increasing the likelihood of falls in older adults and consequently raising the risk of hip fractures (HF).
AIMS
To explore the relationship between the size and density of muscle and subcutaneous adipose tissue (SAT) and the bone mineral density (BMD) of the proximal femur in elderly women with HF.
METHODS
Quantitative computed tomography (QCT) was conducted on the hips of 661 female participants who experienced low-energy acute HFs to measure both areal BMD (aBMD) and volume BMD (vBMD). Measurements were taken for the cross-sectional area (CSA) and density of the muscle around the hip and adjacent SAT. Multivariable linear regression models were applied to assess the relationship between these parameters.
RESULTS
Most increases in the density of the gluteus medius and minimus muscle (G.Med/MinM) were correlated with higher BMD in the femoral neck fracture (FNF) group with osteoporosis. In the FNF group, gluteus maximus muscle (G.MaxM) density was negatively associated with the BMD parameters of the proximal femur in individuals with osteoporosis, while they were positively associated with nonosteoporosis. In the intertrochanteric fracture (ITF) group without osteoporosis, both FN aBMD and FN vBMD showed significant correlations with G.Med/MinM density.
DISCUSSION
In women with HFs, bone and muscle are closely related.
CONCLUSIONS
In older women with HFs, density but not CSA of the G.Med/MinM were associated with BMD parameters of the proximal femur. Osteoporosis may influence the relationship between G.MaxM density and proximal femur BMD in elderly women with FNF.
背景
骨质疏松症和肌肉减少症都与衰老有关，增加了老年人跌倒的可能性，从而增加了髋部骨折（HF）的风险。
目的
探讨老年 HF 女性患者的肌肉和皮下脂肪组织（SAT）的大小和密度与股骨近端骨密度（BMD）之间的关系。
方法
对 661 名经历低能量急性 HF 的女性患者的臀部进行定量计算机断层扫描（QCT），以测量面积 BMD（aBMD）和体积 BMD（vBMD）。测量髋关节周围和相邻 SAT 的肌肉横截面积（CSA）和密度。应用多变量线性回归模型评估这些参数之间的关系。
结果
大多数臀中肌和臀小肌（G.Med/MinM）密度的增加与骨质疏松性股骨颈骨折（FNF）组的 BMD 较高相关。在 FNF 组中，臀大肌（G.MaxM）密度与骨质疏松个体的股骨近端 BMD 参数呈负相关，而与非骨质疏松个体呈正相关。在无骨质疏松的转子间骨折（ITF）组中，FN aBMD 和 FN vBMD 均与 G.Med/MinM 密度呈显著相关。
讨论
在 HF 女性中，骨骼和肌肉密切相关。
结论
在 HF 老年女性中，G.Med/MinM 的密度而不是 CSA 与股骨近端 BMD 参数相关。骨质疏松症可能会影响 FNF 老年女性 G.MaxM 密度与股骨近端 BMD 之间的关系。
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