探讨 CHRNA5、CHRNA3 和 CHRNB4 变异在约旦物质使用障碍遗传图谱中的作用。
Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan.
机构信息
Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Department of Anatomy, College of Medicine, King Khalid University, Abha, 62529, Saudi Arabia.
出版信息
BMC Psychiatry. 2024 Jun 11;24(1):436. doi: 10.1186/s12888-024-05898-7.
BACKGROUND
Substance use disorder (SUD) is a complex illness that can be attributed to the interaction between environmental and genetic factors. The nicotinic receptor gene cluster on chromosome 15 has a plausible association with SUD, particularly with nicotine dependence.
METHODS
This study investigated 15 SNPs within the CHRNA5, CHRNA3, and CHRNB4 genes. Sequencing was used for genotyping 495 Jordanian males with SUD and 497 controls matched for age, gender, and descent.
RESULTS
Our findings revealed that none of the tested alleles or genotypes were correlated with SUD. However, our analysis suggests that the route of substance use was linked to rs1051730 (P value = 0.04), rs8040868 (P value = 0.01) of CHRNA3, and rs16969968 (P value = 0.03) of CHRNA5. Additionally, a correlation was identified between rs3813567 of the CHRNB4 gene and the age at substance use onset (P value = 0.04).
CONCLUSIONS
Variants in CHRNA5, CHRNA3, and CHRNB4 may interact with SUD features that can influence the development and progression of the disorder among Jordanians.
背景
物质使用障碍（SUD）是一种复杂的疾病，可以归因于环境和遗传因素的相互作用。15 号染色体上的烟碱受体基因簇与 SUD 特别是尼古丁依赖有合理的关联。
方法
本研究调查了 CHRNA5、CHRNA3 和 CHRNB4 基因内的 15 个 SNPs。对 495 名患有 SUD 的约旦男性和 497 名年龄、性别和出身相匹配的对照进行测序以进行基因分型。
结果
我们的研究结果表明，没有一个测试的等位基因或基因型与 SUD 相关。然而，我们的分析表明，物质使用途径与 CHRNA3 的 rs1051730（P 值=0.04）、rs8040868（P 值=0.01）和 CHRNA5 的 rs16969968（P 值=0.03）有关。此外，CHRNB4 基因的 rs3813567 与物质使用起始年龄之间存在相关性（P 值=0.04）。
结论
CHRNA5、CHRNA3 和 CHRNB4 中的变体可能与 SUD 特征相互作用，这些特征可能会影响约旦人这种疾病的发展和进展。
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