阿片受体基因多态性的遗传易感性与药物成瘾：候选基因关联研究。
Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study.
机构信息
Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, 22110, Jordan.
出版信息
BMC Psychiatry. 2021 Jan 5;21(1):5. doi: 10.1186/s12888-020-03006-z.
BACKGROUND
Like other complex diseases including drug addiction, genetic factors can interfere with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) were examined for an association with drug addiction among Jordanian males.
METHODS
The study involved 498 addicts, in addition to 496 healthy controls and all from Arab descent.
RESULTS
The findings in this study showed that rs1799971 of the OPRM1 gene was in association with drug addiction for both alleles and genotypes with P-values = 0.002 and 0.01, respectively. In addition, a significant association between the dominant model (A/A vs G/A-G/G) of rs1799971 (OPRM1) and drug addiction (P-value = 0.003, OR = 1.59 (1.17-2.15)) was detected. Moreover, a genetic haplotype (AGGGCGACCCC) of theOPRM1 gene revealed a significant association with drug addiction (P-value = 0.01, OR = 1.56 (1.15-2.12)). We also found that the age of addicts, smoking, and marital status with genetic variants within OPRM1, OPRD1, and OPRK1 genes may be implicated in drug addiction risk.
CONCLUSION
We propose that rs1799971 of the OPRM1gene is a genetic risk factor for drug addiction among Jordanian males.
背景
与包括药物成瘾在内的其他复杂疾病一样，遗传因素可能会干扰疾病的发生。在这项研究中，我们研究了三个阿片类受体基因（OPRM1、OPRD1 和 OPRK1）与约旦男性药物成瘾之间的关联。
方法
该研究涉及 498 名成瘾者，以及 496 名健康对照者，他们均来自阿拉伯裔。
结果
本研究的结果表明，OPRM1 基因的 rs1799971 等位基因和基因型均与药物成瘾相关（P 值分别为 0.002 和 0.01）。此外，rs1799971（OPRM1）的显性模型（A/A 对 G/A-G/G）与药物成瘾之间存在显著关联（P 值=0.003，OR=1.59（1.17-2.15））。此外，OPRM1 基因的遗传单倍型（AGGGCGACCCC）与药物成瘾存在显著关联（P 值=0.01，OR=1.56（1.15-2.12））。我们还发现，成瘾者的年龄、吸烟和婚姻状况与 OPRM1、OPRD1 和 OPRK1 基因内的遗传变异可能与药物成瘾风险有关。
结论
我们提出，OPRM1 基因的 rs1799971 是约旦男性药物成瘾的遗传风险因素。
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