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与梭形细胞成分稀少的化生性胸腺瘤捉迷藏

Hide-and-Seek With Spindle-Cell-Component-Poor Metaplastic Thymoma.

作者信息

Ražanskienė Gintarė, Landsbergis Vilhelmas, Bertašius Vytenis, Norvilas Rimvydas, Mickys Ugnius

机构信息

National Center of Pathology, Vilnius University Hospital Santaros Klinikos, Vilnius, LTU.

Faculty of Medicine, Vilnius University, Vilnius, LTU.

出版信息

Cureus. 2024 May 12;16(5):e60136. doi: 10.7759/cureus.60136. eCollection 2024 May.

Abstract

Metaplastic thymoma is a rare biphasic thymic tumor with indolent behavior and recurrent gene rearrangement. Although the diagnosis of this tumor is usually straightforward based on hematoxylin and eosin (H&E) findings alone, cases with scant spindle-cell ("pseudosarcomatous stroma") components can be easily confused with more commonly occurring type A thymoma. We present a case of metaplastic thymoma with a sparse stroma-like spindle-cell component, discussing its histological and immunohistochemical hints and drawing attention to the visual similarity to type A thymoma. This is also the first published case of metaplastic thymoma with associated psoriasis.

摘要

化生性胸腺瘤是一种罕见的具有惰性生物学行为和复发性基因重排的双相性胸腺肿瘤。尽管仅根据苏木精和伊红(H&E)染色结果通常就能直接诊断该肿瘤,但具有少量梭形细胞(“假肉瘤性间质”)成分的病例可能很容易与更常见的A型胸腺瘤混淆。我们报告一例具有稀疏的间质样梭形细胞成分的化生性胸腺瘤病例,讨论其组织学和免疫组化特征,并提请注意其与A型胸腺瘤在镜下的相似性。这也是首例有银屑病相关报道的化生性胸腺瘤病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd82/11165440/4f6b2538143a/cureus-0016-00000060136-i01.jpg

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