Andrianto Andreas, Sudiana I Ketut, Suprabawati Desak G A
Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Pathology Anatomy, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Iran J Pathol. 2024 Winter;19(1):67-74. doi: 10.30699/IJP.2023.2004468.3126. Epub 2023 Dec 29.
BACKGROUND & OBJECTIVE: Breast cancer recurrence after surgery was a sign that the progress of the disease was continuing. Early detection of breast cancer patients who are at risk requires development of a marker. Alfa smooth muscle actin (α-SMA) plays a role in the local recurrence process of invasive ductal carcinoma (IDC). Currently, existing tumor markers are used to predict the prognosis of breast cancer in general, not the early stages. Therefore, it was thought that finding α-SMA expression might predict early recurrence in early-stage IDC more accurately than others. This study investigated the potential role of α-SMA expression as a predictor of early recurrence in early-stage IDC and its relationship to clinicopathological factors.
The study design was cross-sectional, with data obtained from the medical records of Dr. Koesnadi, General Hospital, Bondowoso, Indonesia. Bivariate and multivariate analysis was performed to analyze data.
We included 50 subjects divided into the local recurrence group (n=25) and the non-local recurrence group (n=25). We found a statistically significant correlation between the incidence of local recurrence in early-stage IDC and the high expression of α-SMA (odd ratio [OR]=23.22, 95% confidence interval [CI]=5.101-105.7, =0.001). Clinicopathological variables and α-SMA expression did not have a significant correlation.
In early-stage IDC, α-SMA expression had the potential to predict and could be an independent prognostic factor for early recurrence.
乳腺癌术后复发是疾病进展仍在继续的标志。早期发现有风险的乳腺癌患者需要开发一种标志物。α平滑肌肌动蛋白（α-SMA）在浸润性导管癌（IDC）的局部复发过程中起作用。目前，现有的肿瘤标志物通常用于预测乳腺癌的预后，而非早期阶段。因此，人们认为检测α-SMA表达可能比其他方法更准确地预测早期IDC的早期复发。本研究调查了α-SMA表达作为早期IDC早期复发预测指标的潜在作用及其与临床病理因素的关系。
本研究设计为横断面研究，数据来自印度尼西亚邦多沃索市Koesnadi综合医院的病历。采用双变量和多变量分析来分析数据。
我们纳入了50名受试者，分为局部复发组（n=25）和非局部复发组（n=25）。我们发现早期IDC局部复发的发生率与α-SMA的高表达之间存在统计学显著相关性（比值比[OR]=23.22，95%置信区间[CI]=5.101-105.7，P=0.001）。临床病理变量与α-SMA表达无显著相关性。
在早期IDC中，α-SMA表达有预测潜力，可能是早期复发的独立预后因素。
