Jo Joon-Hyung, Chung Hyun Woo, So Young, Yoo Young Bum, Park Kyoung Sik, Nam Sang Eun, Lee Eun Jeong, Noh Woo Chul
Department of Nuclear Medicine, Konkuk University Medical Center, Seoul 05030, Korea.
Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul 05029, Korea.
Diagnostics (Basel). 2022 Mar 12;12(3):694. doi: 10.3390/diagnostics12030694.
This study investigated the prognostic value of FDG PET/CT radiomic features for predicting recurrence in patients with early breast invasive ductal carcinoma (IDC). The medical records of consecutive patients who were newly diagnosed with primary breast IDC after curative surgery were reviewed. Patients who received any neoadjuvant treatment before surgery were not included. FDG PET/CT radiomic features, such as a maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), skewness, kurtosis, entropy, and uniformity, were measured for the primary breast tumor using LIFEx software to evaluate recurrence-free survival (RFS). A total of 124 patients with early breast IDC were evaluated. Eleven patients had a recurrence (8.9%). Univariate survival analysis identified large tumor size (>2 cm, p = 0.045), high Ki-67 expression (≥30%, p = 0.017), high AJCC prognostic stage (≥II, p = 0.044), high SUVmax (≥5.0, p = 0.002), high MTV (≥3.25 mL, p = 0.044), high TLG (≥10.5, p = 0.004), and high entropy (≥3.15, p = 0.003) as significant predictors of poor RFS. After multivariate survival analysis, only high MTV (p = 0.045) was an independent prognostic predictor. Evaluation of the MTV of the primary tumor by FDG PET/CT in patients with early breast IDC provides useful prognostic information regarding recurrence.
本研究调查了氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）影像组学特征对早期乳腺浸润性导管癌（IDC）患者复发的预测价值。回顾了根治性手术后新诊断为原发性乳腺IDC的连续患者的病历。排除术前接受过任何新辅助治疗的患者。使用LIFEx软件测量原发性乳腺肿瘤的FDG PET/CT影像组学特征，如最大标准化摄取值（SUVmax）、代谢肿瘤体积（MTV）、总病变糖酵解（TLG）、偏度、峰度、熵和均匀性，以评估无复发生存期（RFS）。共评估了124例早期乳腺IDC患者。11例患者出现复发（8.9%）。单因素生存分析确定肿瘤体积大（>2 cm，p = 0.045）、Ki-67高表达（≥30%，p = 0.017）、美国癌症联合委员会（AJCC）预后分期高（≥II期，p = 0.044）、SUVmax高（≥5.0，p = 0.002）、MTV高（≥3.25 mL，p = 0.044）、TLG高（≥10.5，p = 0.004）和熵高（≥3.15，p = 0.003）是RFS不良的显著预测因素。多因素生存分析后，只有MTV高（p = 0.045）是独立的预后预测因素。通过FDG PET/CT评估早期乳腺IDC患者原发性肿瘤的MTV可提供有关复发的有用预后信息。
