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伴有印戒样细胞成分的舌根部硬化性微囊性腺癌：1例罕见病例

Sclerosing Microcystic Adenocarcinoma of the Base of Tongue with Signet Ring-Like Cell Component: A Rare Case.

作者信息

Mokhles Parisa, Sadeghipour Alireza, Kadivar Maryam, Shayanfar Nasrin, Keshtpour Amlashi Zahra, Alizade Pahlavan Pegah, Shafiei Ashkan

机构信息

School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.

出版信息

Iran J Pathol. 2024 Winter;19(1):107-113. doi: 10.30699/IJP.2023.1989943.3068. Epub 2023 Dec 29.

DOI:10.30699/IJP.2023.1989943.3068
PMID:38864089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11164311/
Abstract

Sclerosing microcystic adenocarcinoma (SMA) is an uncommon neoplasm of the oral cavity, with only 14 reported cases documented in the literature. We present a case of SMA in a 65-year-old woman with a history of high-grade lymphoma who developed clear cell changes in the deep muscular layer of the tongue. Currently, the diagnosis of SMA relies on careful morphological evaluation and the exclusion of other potential differential diagnoses.

摘要

硬化性微囊性腺癌（SMA）是一种罕见的口腔肿瘤，文献中仅记载了14例报告病例。我们报告一例65岁女性的SMA病例，该患者有高级别淋巴瘤病史，其舌深层肌肉层出现了透明细胞改变。目前，SMA的诊断依赖于仔细的形态学评估以及排除其他潜在的鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87bb/11164311/092a47939853/ijp-19-107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87bb/11164311/884c6243525c/ijp-19-107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87bb/11164311/556350fe58ac/ijp-19-107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87bb/11164311/092a47939853/ijp-19-107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87bb/11164311/884c6243525c/ijp-19-107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87bb/11164311/556350fe58ac/ijp-19-107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87bb/11164311/092a47939853/ijp-19-107-g003.jpg

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本文引用的文献

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2
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Ann Diagn Pathol. 2021 Oct;54:151806. doi: 10.1016/j.anndiagpath.2021.151806. Epub 2021 Aug 16.
3
Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations: Clinicopathologic and Molecular Characterization With Proposal for a Unified Classification.
涎腺黏液腺癌是一种组织学上具有多样性的单一实体，存在 AKT1 E17K 突变的复发性：临床病理和分子特征分析及提出的统一分类建议。
Am J Surg Pathol. 2021 Oct 1;45(10):1337-1347. doi: 10.1097/PAS.0000000000001688.
4
Sequencing of Sclerosing Microcystic Adenocarcinoma Identifies Mutational Burden and Somatic Variants Associated With Tumorigenesis.硬化性微囊性腺癌的测序鉴定出与肿瘤发生相关的突变负担和体细胞变异。
Anticancer Res. 2020 Nov;40(11):6375-6379. doi: 10.21873/anticanres.14658.
5
Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study.多形性腺癌（PAC）和涎腺筛状腺癌（CASG）的组织学分类和分子特征：一项国际观察者间研究。
Am J Surg Pathol. 2020 Apr;44(4):545-552. doi: 10.1097/PAS.0000000000001431.
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