头颈部外照射治疗涎腺恶性肿瘤的时机选择。

Timing of postoperative radiation therapy for major salivary gland cancers.

机构信息

Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

Division of Head and Neck Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

出版信息

Head Neck. 2024 Nov;46(11):2861-2869. doi: 10.1002/hed.27845. Epub 2024 Jun 12.

DOI:10.1002/hed.27845

PMID:38864240

Abstract

BACKGROUND

The impact of timing of PORT initiation for major salivary gland cancers on survival is unknown. We aim to examine the impact of PORT timeliness on overall survival (OS) of patients with major salivary gland cancers.

METHODS

This was a cross-sectional analysis using data from the National Cancer Database (2004-2017) and included patients with major salivary gland cancer treated with surgery and PORT.

RESULTS

In total, 5701 patients were included (3133 [55%] male, 4644 [82%] white, mean age 59 ± 16 years). For the overall cohort, PORT >6 weeks was not associated with decreased OS (1.00 aHR, 95% CI 0.89-1.11). When specifically examining patients with mucoepidermoid carcinoma, PORT >6 weeks was associated with a decreased OS (1.27 aHR, 95% CI 1.01-1.58).

CONCLUSIONS

Overall, this analysis did not demonstrate a survival benefit for initiating PORT within 6 weeks for patients with salivary gland malignancies. Subset analysis did support initiating PORT within 6 weeks after resection for patients with mucoepidermoid carcinomas. This was not demonstrated in other major salivary gland cancer histologies.

摘要

背景

原发灶区域淋巴结清扫术后放疗（PORT）起始时机对大涎腺癌患者生存的影响尚不清楚。本研究旨在探讨大涎腺癌患者 PORT 及时性对总生存期（OS）的影响。

方法

这是一项基于美国国家癌症数据库（2004-2017 年）的回顾性队列研究，纳入了接受手术和 PORT 治疗的大涎腺癌患者。

结果

共纳入 5701 例患者（3133 例男性[55%]，4644 例白人[82%]，平均年龄 59±16 岁）。对于全队列，PORT 起始时间＞6 周与 OS 降低无关（1.00 aHR，95%CI 0.89-1.11）。当专门分析黏液表皮样癌患者时，PORT 起始时间＞6 周与 OS 降低相关（1.27 aHR，95%CI 1.01-1.58）。