Molybdenum Disulfide-Supported Cuprous Oxide Nanocomposite for Near-Infrared-I Light-Responsive Synergistic Antibacterial Therapy.

Drug-resistant bacterial infections pose a serious threat to human health; thus, there is an increasingly growing demand for nonantibiotic strategies to overcome drug resistance in bacterial infections. Mild photothermal therapy (PTT), as an attractive antibacterial strategy, shows great potential application due to its good biocompatibility and ability to circumvent drug resistance. However, its efficiency is limited by the heat resistance of bacteria. Herein, CuO@MoS, a nanocomposite, was constructed by the growth of CuO nanoparticles (NPs) on the surface of MoS nanosheets, which provided a controllable photothermal therapeutic effect of MoS and the intrinsic catalytic properties of CuO NPs, achieving a synergistic effect to eradicate multidrug-resistant bacteria. Transcriptome sequencing (RNA-seq) results revealed that the antibacterial process was related to disrupting the membrane transport system, phosphorelay signal transduction system, oxidative stress response system, as well as the heat response system. Animal experiments indicated that CuO@MoS could effectively treat wounds infected with methicillin-resistant . In addition, satisfactory biocompatibility made CuO@MoS a promising antibacterial agent. Overall, our results highlight the CuO@MoS nanocomposite as a promising solution to combating resistant bacteria without inducing the evolution of antimicrobial resistance.