FAT10 表达在恶性肿瘤中的预后意义：系统评价和荟萃分析。
Prognostic significance of FAT10 expression in malignant tumors: a systematic review and meta-analysis.
机构信息
Department of Radiation Oncology, Division of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
College of Management, Sichuan Agricultural University, Chengdu, 611130, P.R. China.
出版信息
Future Oncol. 2024;20(21):1505-1514. doi: 10.1080/14796694.2024.2357531. Epub 2024 Jun 12.
FAT10, a ubiquitin-like modifier protein, influences apoptosis, DNA damage response and tumor growth, with unclear effects on cancer prognosis. We reviewed expression's impact on malignancy prognosis through a systematic review and meta-analysis, including studies up to September 2023 from PubMed, EMBASE and Web of Science. From 18 studies involving 2513 patients, overexpression significantly reduced overall and disease-free survival across various tumors, indicating correlations with advanced disease stage, poor differentiation, lymph node metastasis and larger tumor size. 's overexpression suggests a negative prognostic value in cancer, meriting further investigation. CRD42023431287.
FAT10，一种泛素样修饰蛋白，影响细胞凋亡、DNA 损伤反应和肿瘤生长，但对癌症预后的影响尚不清楚。我们通过系统评价和荟萃分析回顾了表达对恶性肿瘤预后的影响，包括截至 2023 年 9 月来自 PubMed、EMBASE 和 Web of Science 的研究。从 18 项涉及 2513 名患者的研究中，我们发现 FAT10 过表达显著降低了各种肿瘤的总生存率和无病生存率，这表明与晚期疾病阶段、低分化、淋巴结转移和更大的肿瘤大小相关。FAT10 过表达提示癌症预后不良，值得进一步研究。CRD42023431287。
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