匹莫齐特调节促黄体生成激素释放激素对非洲鲶鱼（胡子鲶）促性腺激素释放的影响。
Pimozide modulates the luteinizing hormone-releasing hormone effect on gonadotrophin release in the African catfish, Clarias lazera.
作者信息
de Leeuw R, Resink J W, Rooyakkers E J, Goos H J
出版信息
Gen Comp Endocrinol. 1985 Apr;58(1):120-7. doi: 10.1016/0016-6480(85)90144-3.
In the African catfish the effect of (i) the dopamine antagonist pimozide (PIM), (ii) a luteinizing hormone-releasing hormone analog (LH-RHa), and (iii) a combination of these substances on gonadotrophin (GTH) release and on ovulation was investigated. PIM alone increased plasma GTH levels in juvenile catfish but was ineffective in mature animals. LH-RHa increased plasma GTH levels in both juvenile and mature catfish and within 12 hr after the injection a high rate of ovulation (80%) was observed. PIM potentiated the LH-RHa effect on GTH release and ovulation. It was concluded that dopamine does not effect the GTH release directly, but modulates the effect of endogenous and exogenous gonadotrophin-releasing hormone.
在非洲鲶鱼中，研究了以下因素对促性腺激素（GTH）释放和排卵的影响：（i）多巴胺拮抗剂匹莫齐特（PIM）；（ii）促黄体生成素释放激素类似物（LH-RHa）；（iii）这些物质的组合。单独使用PIM可提高幼鲶血浆GTH水平，但对成年动物无效。LH-RHa可提高幼鲶和成年鲶鱼的血浆GTH水平，注射后12小时内观察到高排卵率（80%）。PIM增强了LH-RHa对GTH释放和排卵的作用。得出的结论是，多巴胺不直接影响GTH释放，但可调节内源性和外源性促性腺激素释放激素的作用。
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