Katz A L, Nashel D J, Goard C P, Bauer H
South Med J. 1979 Nov;72(11):1463-6. doi: 10.1097/00007611-197911000-00034.
The coexistence of scleroderma and malignancy is well documented. The case presented here is unique, however, as it is the first report of the occurrence of diffuse histiocytic lymphoma and pemphigus vulgaris in a patient with scleroderma. Because of this unusual triad of diseases, the possibility of a common pathogenetic basis was examined. A review of the literature confirms that each disorder does have immunologic abnormalities. It is suggested that an aberrant immune response, specifically impaired T-cell function, is responsible for the emergence of disease of this patient.
硬皮病与恶性肿瘤并存已有充分文献记载。然而，此处所呈现的病例是独特的，因为这是首例关于硬皮病患者发生弥漫性组织细胞淋巴瘤和寻常型天疱疮的报告。鉴于这三种疾病的不寻常组合，对其共同发病机制的可能性进行了研究。文献回顾证实每种疾病确实都存在免疫异常。有人提出异常的免疫反应，特别是T细胞功能受损，是该患者发病的原因。
