Strauchen J A
Hematol Oncol. 1985 Jan-Mar;3(1):11-23. doi: 10.1002/hon.2900030103.
The distribution of lectin binding receptors in normal human lymphoid tissue and follicular (nodular) lymphoma was studied in tissue sections using a panel of lectin-peroxidase and lectin-fluorescein conjugates: Concanavalin A (Con A), Peanut agglutinin (PNA), Lotus tetragonolobus agglutinin (LTA), Soybean agglutinin, Ulex europeus and Bandeiraea simplicifolia. Two lectins studied, PNA and LTA were found to bind selectively to the cell membranes of follicular centre lymphocytes in normal lymphoid tissue, and to the neoplastic cells of follicular (nodular) lymphomas. Con A, in contrast, bound selectively to follicular centre macrophages (tingible body cells) and identified in follicular (nodular) lymphomas a population of dendritic-like cells not otherwise recognized and possibly corresponding to dendritic cells identified ultrastructurally. Follicular (nodular) lymphomas share the lectin binding properties of non-neoplastic follicular centres. The expression of receptors for lectins with blood group activity (PNA T-like, LTA H-like) on follicular lymphocytes may play a role in follicle formation.
利用一组凝集素-过氧化物酶和凝集素-荧光素偶联物：刀豆球蛋白A（Con A）、花生凝集素（PNA）、四角豆凝集素（LTA）、大豆凝集素、荆豆凝集素和单叶豆凝集素，在组织切片中研究了凝集素结合受体在正常人淋巴组织和滤泡性（结节性）淋巴瘤中的分布。研究发现，所研究的两种凝集素，即PNA和LTA，选择性地结合正常淋巴组织中滤泡中心淋巴细胞的细胞膜，以及滤泡性（结节性）淋巴瘤的肿瘤细胞。相比之下，Con A选择性地结合滤泡中心巨噬细胞（核碎片细胞），并在滤泡性（结节性）淋巴瘤中识别出一群未被其他方式识别的树突状样细胞，可能与超微结构鉴定的树突状细胞相对应。滤泡性（结节性）淋巴瘤具有非肿瘤性滤泡中心的凝集素结合特性。滤泡淋巴细胞上具有血型活性的凝集素受体（PNA T样、LTA H样）的表达可能在滤泡形成中起作用。
