Department of Viral Transformation, Leibniz Institute of Virology (LIV), Martinistraße 52, 20251 Hamburg, Germany.
Department of Viral Transformation, Leibniz Institute of Virology (LIV), Martinistraße 52, 20251 Hamburg, Germany.
Curr Opin Virol. 2024 Aug;67:101413. doi: 10.1016/j.coviro.2024.101413. Epub 2024 Jun 11.
Oncogenic viruses contribute to 15% of global human cancers. To achieve that, virus-encoded oncoproteins deregulate cellular transcription, antagonize common cellular pathways, and thus drive cell transformation. Notably, adenoviruses were the first human viruses proven to induce cancers in diverse animal models. Over the past decades, human adenovirus (HAdV)-mediated oncogenic transformation has been pivotal in deciphering underlying molecular mechanisms. Key adenovirus oncoproteins, encoded in early regions 1 (E1) and 4 (E4), co-ordinate these processes. Among the different adenovirus species, the most extensively studied HAdV-C5 displays lower oncogenicity than HAdV-A12. A complete understanding of the different HAdV-A12 and HAdV-C5 oncoproteins in virus-mediated cell transformation, as summarized here, is relevant for adenovirus research and offers broader insights into viral transformation and oncogenesis.
致癌病毒导致全球 15%的人类癌症。为达到这一目的，病毒编码的致癌蛋白会使细胞转录失调，拮抗常见的细胞途径，从而驱动细胞转化。值得注意的是，腺病毒是首批被证明能在多种动物模型中诱发癌症的人类病毒。在过去的几十年中，人类腺病毒（HAdV）介导的致癌转化在解析潜在的分子机制方面发挥了关键作用。早期区域 1（E1）和 4（E4）编码的关键腺病毒致癌蛋白共同协调这些过程。在不同的腺病毒物种中，研究最为广泛的 HAdV-C5 比 HAdV-A12 的致癌性更低。这里总结的 HAdV-A12 和 HAdV-C5 致癌蛋白在病毒介导的细胞转化中的不同作用，对于腺病毒研究具有重要意义，并为病毒转化和致癌提供了更广泛的见解。
