Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Immunity. 2024 Jun 11;57(6):1184-1186. doi: 10.1016/j.immuni.2024.05.014.
The mechanisms that make and break CD8 T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8 T cells rapidly adopt an epigenetically and transcriptionally distinct cell state and exhibit impaired protein translation. Breaking tolerance requires both inflammation and increased antigen exposure to augment MYC expression and restore translation.
自身抗原诱导的 CD8 T 细胞耐受的建立和打破机制仍不清楚。在本期《免疫》杂志中，Van Der Byl 等人表明，耐受的 CD8 T 细胞迅速采用一种表观遗传和转录上不同的细胞状态，并表现出翻译受损。打破耐受需要炎症和增加抗原暴露，以增强 MYC 表达并恢复翻译。
