School of Clinical Medicine, Jiangsu Health Vocational College, No. 69, Huangshan Ling Road, Pukou Distric, Nanjing, Jiangsu 210029, China; Nanjing Medical University, Nanjing 210029, Jiangsu, China.
School of Clinical Medicine, Jiangsu Health Vocational College, No. 69, Huangshan Ling Road, Pukou Distric, Nanjing, Jiangsu 210029, China.
Clin Res Hepatol Gastroenterol. 2024 Aug;48(7):102393. doi: 10.1016/j.clinre.2024.102393. Epub 2024 Jun 10.
Inflammation played a critical role in non-alcoholic fatty liver disease (NAFLD). Here, we aimed to explore the relationship between inflammatory biomarkers and the prevalence of NAFLD and hepatic fibrosis in US participants.
Individuals with complete data from National Health and Nutrition Examination Survey (NHANES), 2017-2020 pre-pandemic cycle dataset were referred to this study. We identified NAFLD by vibration-controlled transient elastography (VCTE) on the basis of controlling attenuation parameter (CAP) ≥274dB/m. Liver fibrosis was confirmed by liver stiffness measurement (LSM) ≥8.2kPa. Multivariate logistic regression models were applied to estimate the correlations between inflammatory biomarkers and the prevalence of NAFLD and hepatic fibrosis based on sample weights.
All together 5026 subjects were incorporated into the study cohort. Among these subjects, 2209 were classified as having NAFLD, and 8.35 % were diagnosed with hepatic fibrosis. Pan immune inflammatory value (PIV), instead of systemic immune inflammatory index (SII), was positively correlated with the rate of NAFLD or hepatic fibrosis. Subgroup analysis for NAFLD revealed that the positive relationships of the PIV existed in males (OR=1.52, 95 % CI: 1.01-2.28, p = 0.046) and participants below 60 years of age (OR=1.49, 95 % CI: 1.05-2.1, p = 0.028). Moreover, subgroup analysis for hepatic fibrosis revealed that the positive relationships of the PIV existed in females (OR=2.09, 95 % CI: 1.2-3.63, p = 0.014) and participants below 60 years of age (OR=1.74, 95 % CI: 1.09-2.77, p = 0.023).
A higher PIV, but not SII, is associated with a higher likelihood of NAFLD and liver fibrosis, suggesting that the PIV is a more valuable inflammatory marker for assessing NAFLD and liver fibrosis in participants, especially for those who are below 60 years of age.
炎症在非酒精性脂肪性肝病（NAFLD）中起着关键作用。在这里，我们旨在探讨美国参与者中炎症生物标志物与 NAFLD 和肝纤维化患病率之间的关系。
本研究纳入了 2017-2020 年大流行前周期国家健康和营养检查调查（NHANES）中具有完整数据的个体。我们根据控制衰减参数（CAP）≥274dB/m 确定 NAFLD。通过肝脏硬度测量（LSM）≥8.2kPa 确认肝纤维化。基于样本权重，应用多变量逻辑回归模型估计炎症生物标志物与 NAFLD 和肝纤维化患病率之间的相关性。
共有 5026 名受试者纳入研究队列。在这些受试者中，2209 名被归类为患有 NAFLD，8.35%被诊断为肝纤维化。全免疫炎症值（PIV）而不是全身免疫炎症指数（SII）与 NAFLD 或肝纤维化的发生率呈正相关。NAFLD 的亚组分析显示，PIV 的阳性关系存在于男性（OR=1.52，95%CI：1.01-2.28，p=0.046）和 60 岁以下的参与者（OR=1.49，95%CI：1.05-2.1，p=0.028）中。此外，肝纤维化的亚组分析显示，PIV 的阳性关系存在于女性（OR=2.09，95%CI：1.2-3.63，p=0.014）和 60 岁以下的参与者（OR=1.74，95%CI：1.09-2.77，p=0.023）中。
较高的 PIV，但不是 SII，与更高的 NAFLD 和肝纤维化可能性相关，这表明 PIV 是评估参与者中 NAFLD 和肝纤维化的更有价值的炎症标志物，尤其是对于 60 岁以下的参与者。
