MACC1表达在胃癌患者中的预后风险分层价值

Prognostic risk stratification value of MACC1 expression in patients with gastric cancer.

作者信息

Zhang Xia, Feng Xing-Jun, Han Qiu-Yue, Zhang Jian-Gang, Yan Wei-Hua, Lin Aifen

机构信息

Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, People's Republic of China.

Biological Resource Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, People's Republic of China.

出版信息

Clin Transl Oncol. 2025 Jan;27(1):117-125. doi: 10.1007/s12094-024-03550-0. Epub 2024 Jun 13.

DOI:10.1007/s12094-024-03550-0

PMID:38867026

Abstract

BACKGROUND

The prognostic significance of metastasis-associated in colon cancer-1 (MACC1) has been explored in a variety of malignancies. However, its clinical relevance in patients with gastric cancer (GC) is limited, also remains controversial.

METHOD

In this study, we retrospectively evaluated the prognostic value of lesion MACC1 expression in 347 GC patients. Lesion MACC1 expression was analyzed with immunohistochemistry and grouped as MACC1 (n = 172) and MACC1 (n = 175) cases.

RESULTS

Data revealed that the degree of MACC1 expression is not related to patient sex, age and disease stage (all p > 0.05). Survival analysis showed that only post-operation advanced pT (p = 0.018), pN (p < 0.001), pM (p = 0.001) and AJCC stages (p < 0.001) are significantly associated with shorter survival, while no obvious difference was observed between MACC1 and MACC1 cases (p = 0.158). However, we found that survival for female (p = 0.032), older (p = 0.028), and early disease stage (pT stage I + II, p = 0.033) patients with MACC1 are remarkably worse than those with MACC1.

CONCLUSION

In summary, our findings revealed that, though MACC1 expression is not associated with the survival of the whole cohort, the prognostic risk stratification value of lesion MACC1 expression in subgroups of patients with gastric cancer should be noted.

摘要

背景

在多种恶性肿瘤中已对结肠癌转移相关蛋白1（MACC1）的预后意义进行了探索。然而，其在胃癌（GC）患者中的临床相关性有限，且仍存在争议。

方法

在本研究中，我们回顾性评估了347例GC患者病变组织中MACC1表达的预后价值。采用免疫组织化学分析病变组织中MACC1表达，并分为MACC1阳性组（n = 172）和MACC1阴性组（n = 175）。

结果

数据显示，MACC1表达程度与患者性别、年龄和疾病分期均无关（所有p > 0.05）。生存分析表明，仅术后进展期pT（p = 0.018）、pN（p < 0.001）、pM（p = 0.001）和美国癌症联合委员会（AJCC）分期（p < 0.001）与较短生存期显著相关，而MACC1阳性组和MACC1阴性组之间未观察到明显差异（p = 0.158）。然而，我们发现MACC1阳性的女性患者（p = 0.032）、老年患者（p = 0.028）和疾病早期（pT分期I + II，p = 0.033）患者的生存期明显短于MACC1阴性患者。