结肠癌转移相关基因-1 在胃癌中的临床病理及预后意义：一项荟萃分析。

Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 in gastric cancer: A meta-analysis.

机构信息

1 Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, P.R. China.

2 Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Huai'an, P.R. China.

出版信息

Int J Biol Markers. 2019 Mar;34(1):27-32. doi: 10.1177/1724600818813634. Epub 2019 Mar 10.

DOI:10.1177/1724600818813634

PMID:30854927

Abstract

BACKGROUND

The gene metastasis-associated in colon cancer-1 (MACC1) has been reported to be overexpressed in diverse human malignancies, and an increasing amount of evidence suggests that its overexpression is associated with the development and progression of many human tumors. However, the prognostic and clinicopathological value of MACC1 in gastric cancer remains inconclusive. Therefore, we conducted this meta-analysis to investigate the effect of positive MACC1 expression on clinicopathological features and survival outcomes in gastric cancer.

METHODS

Medline, Web of Science, and EMBASE databases were searched for relevant articles published up to 10 April 2018. The correlation of MACC1 expression levels with overall survival and clinicopathological features was analyzed.

RESULTS

In this meta-analysis, nine studies with a total of 2103 gastric cancer patients were included. Our results showed that high expression of MACC1 was significantly related to a poor overall survival. Moreover, our meta-analysis showed that MACC1 overexpression was significantly linked to distant metastasis and vascular invasion. There were no significant correlations between positive MACC1 expression and gender, localization, tumor-node-metastasis (TNM) stage, tumor extent (T stage) and lymph node involvement (N stage).

CONCLUSIONS

MACC1 expression levels can serve as a novel prognostic factor in gastric cancer patients.

摘要

背景

结肠癌转移相关基因-1（MACC1）在多种人类恶性肿瘤中过度表达，越来越多的证据表明其过度表达与许多人类肿瘤的发生和发展有关。然而，MACC1 在胃癌中的预后和临床病理价值仍存在争议。因此，我们进行了这项荟萃分析，以探讨 MACC1 阳性表达对胃癌临床病理特征和生存结局的影响。

方法

检索了 Medline、Web of Science 和 EMBASE 数据库，截至 2018 年 4 月 10 日，共纳入了 9 项研究，共 2103 例胃癌患者。分析了 MACC1 表达水平与总生存及临床病理特征的相关性。

结果

本荟萃分析共纳入 9 项研究，共 2103 例胃癌患者。结果表明，MACC1 高表达与总体生存率降低显著相关。此外，我们的荟萃分析显示，MACC1 过表达与远处转移和血管侵犯显著相关。MACC1 阳性表达与性别、定位、肿瘤-淋巴结-转移（TNM）分期、肿瘤程度（T 分期）和淋巴结受累（N 分期）均无显著相关性。