Wu Jie, Liu Nian, Chen Jing, Tao Qian, Li Qiuqiu, Li Jie, Chen Xiang, Peng Cong
The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Research (Wash D C). 2024 Jun 12;7:0351. doi: 10.34133/research.0351. eCollection 2024.
The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions. Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position, the TCA cycle remains indispensable for tumor cells as a hub for the metabolic linkage and interconversion of glucose, lipids, and certain amino acids. TCA intermediates such as citrate, α-ketoglutarate, succinate, and fumarate are altered in tumors, and they regulate the tumor metabolism, signal transduction, and immune environment to affect tumorigenesis and tumor progression. This article provides a comprehensive review of the modifications occurring in tumor cells in relation to the intermediates of the TCA cycle, which affects tumor pathogenesis and current therapeutic strategy for therapy through targeting TCA cycle in cancer cells.
三羧酸（TCA）循环能够在有氧条件下为生理活动提供足够的能量。尽管肿瘤代谢重编程使有氧糖酵解占据主导地位，但TCA循环作为葡萄糖、脂质和某些氨基酸代谢联系与相互转化的枢纽，对肿瘤细胞而言仍然不可或缺。柠檬酸、α-酮戊二酸、琥珀酸和富马酸等TCA中间产物在肿瘤中发生改变，它们调节肿瘤代谢、信号转导和免疫环境，从而影响肿瘤发生和肿瘤进展。本文全面综述了肿瘤细胞中与TCA循环中间产物相关的修饰，这些修饰影响肿瘤发病机制以及目前通过靶向癌细胞中的TCA循环进行治疗的策略。
