Lazzari Ludovico, Donzelli Stefano, Tordini Alessandra, Parise Antonio, Pirozzi Ciro, Di Meo Federica, Marallo Carmine, Pace Vincenzo, Marini Chiara, Carreras Giovanni
SSD of Clinical and Interventional Arrhythmology, 'S. Maria', Terni.
Cardiology, University of Perugia.
Eur Heart J Suppl. 2024 Apr 17;26(Suppl 1):i44-i48. doi: 10.1093/eurheartjsupp/suae016. eCollection 2024 Apr.
Arrhythmic storm is a clinical emergency associated with high mortality, which requires multi-disciplinary management. Reprogramming of the implantable cardiac defibrillator (ICD) aimed at reducing shocks, adrenergic blockade using beta-blockers, sedation/anxiolysis, and blockade of the stellate ganglion represent the first simple and effective manoeuvres, but further suppression of arrhythmias with antiarrhythmics is often required. A low-risk patient (e.g. monomorphic ventricular tachycardia, functioning ICD, and haemodynamically stable) should be managed with a beta-blocker (possibly non-selective) plus amiodarone, in addition to sedation with a benzodiazepine or dexmedetomidine; in patients at greater risk (high burden and haemodynamic instability), autonomic modulation with blockade of the stellate ganglion and the addition of a second antiarrhythmic (lidocaine) should be considered. In patients refractory to these measures, with advanced heart failure, general anaesthesia with intubation and the establishment of a haemodynamic circulatory support should be considered. Ablation, performed early, appears to be superior in terms of mortality and reduction of future shocks compared with titration of antiarrhythmics.
心律失常风暴是一种与高死亡率相关的临床急症,需要多学科管理。旨在减少电击次数的植入式心脏除颤器(ICD)重新编程、使用β受体阻滞剂进行肾上腺素能阻断、镇静/抗焦虑以及星状神经节阻断是首先采用的简单有效的措施,但通常还需要使用抗心律失常药物进一步抑制心律失常。低风险患者(如单形性室性心动过速、ICD功能正常且血流动力学稳定)除使用苯二氮䓬类药物或右美托咪定镇静外,应使用β受体阻滞剂(可能是非选择性的)加胺碘酮进行治疗;对于风险较高的患者(高负荷且血流动力学不稳定),应考虑进行星状神经节阻断的自主神经调节并加用第二种抗心律失常药物(利多卡因)。对于对这些措施无效且伴有晚期心力衰竭的患者,应考虑进行插管全身麻醉并建立血流动力学循环支持。与抗心律失常药物滴定相比,早期进行消融在死亡率和减少未来电击次数方面似乎更具优势。