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利拉鲁肽通过上调心房钠尿肽（ANP）的表达水平来改善腹主动脉缩窄（TAC）诱导的心脏肥大和心力衰竭。

Liraglutide ameliorates TAC-induced cardiac hypertrophy and heart failure by upregulating expression level of ANP expression.

作者信息

Li Ruisha, Zhang Keyin, Xu Zhenjun, Yu Yanrong, Wang Dongjin, Li Kai, Liu Wenxue, Pan Jun

机构信息

Institute of Cardiothoracic Vascular Disease, Department of Cardio-Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

Department of Cardio-Thoracic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

出版信息

Heliyon. 2024 May 31;10(11):e32229. doi: 10.1016/j.heliyon.2024.e32229. eCollection 2024 Jun 15.

DOI:10.1016/j.heliyon.2024.e32229
PMID:38868006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11168427/
Abstract

Recent studies have underscored the cardioprotective properties of liraglutide. This research explores its impact on cardiac hypertrophy and heart failure following transverse aortic constriction (TAC). We found that liraglutide administration markedly ameliorated cardiac hypertrophy, fibrosis, and function. These benefits correlated with increased ANP expression and reduced activity in the calcineurin A/NFATc3 signaling pathway. Moreover, liraglutide mitigated ER stress and cardiomyocyte apoptosis, and enhanced autophagy. Notably, the positive effects of liraglutide diminished when co-administered with A71915, an ANP inhibitor, suggesting that ANP upregulation is critical to its cardioprotective mechanism.

摘要

近期研究强调了利拉鲁肽的心脏保护特性。本研究探讨了其对主动脉缩窄（TAC）后心脏肥大和心力衰竭的影响。我们发现，给予利拉鲁肽可显著改善心脏肥大、纤维化和功能。这些益处与心房钠尿肽（ANP）表达增加以及钙调神经磷酸酶A/NFATc3信号通路活性降低相关。此外，利拉鲁肽减轻了内质网应激和心肌细胞凋亡，并增强了自噬。值得注意的是，当与ANP抑制剂A71915联合使用时，利拉鲁肽的积极作用减弱，这表明ANP上调对其心脏保护机制至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/475289c7aceb/mmcfigs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/371554c642c0/gr1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/92f725062528/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/39fce5ab50ee/gr4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/0378c847e944/mmcfigs2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/475289c7aceb/mmcfigs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/371554c642c0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/69a6e4f6fa77/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/92f725062528/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/39fce5ab50ee/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/99aeee8a68c7/mmcfigs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/0378c847e944/mmcfigs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/629c6e45c0b5/mmcfigs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/ebd9967e17d0/mmcfigs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/23afe2f5c4e2/mmcfigs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/11168427/475289c7aceb/mmcfigs6.jpg

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