GLP-1 (Glucagon-Like Peptide-1) Plays a Role in Carotid Chemoreceptor-Mediated Sympathoexcitation and Hypertension.
作者信息
Zucker Irving H, Wang Han-Jun, Schultz Harold D
机构信息
Department of Cellular and Integrative Physiology (I.H.Z., H.D.S.), University of Nebraska Medical Center.
Department of Anesthesiology (H.W.), University of Nebraska Medical Center.
出版信息
Circ Res. 2022 Mar 4;130(5):708-710. doi: 10.1161/CIRCRESAHA.122.320799. Epub 2022 Mar 3.
Abstract
摘要
相似文献
1
GLP-1 (Glucagon-Like Peptide-1) Plays a Role in Carotid Chemoreceptor-Mediated Sympathoexcitation and Hypertension.胰高血糖素样肽-1（GLP-1）在颈动脉化学感受器介导的交感神经兴奋和高血压中起作用。
Circ Res. 2022 Mar 4;130(5):708-710. doi: 10.1161/CIRCRESAHA.122.320799. Epub 2022 Mar 3.
2
Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men.健康年轻男性肌肉交感神经活动和通气的中枢和外周化学感受反射调节的同时评估。
J Physiol. 2019 Jul;597(13):3281-3296. doi: 10.1113/JP277691. Epub 2019 May 28.
3
Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.慢性间歇性低氧对化学反射介导的交感神经兴奋的全身、细胞和分子分析
Exp Physiol. 2007 Jan;92(1):39-44. doi: 10.1113/expphysiol.2006.036434. Epub 2006 Nov 23.
4
Chemoreflexes--physiology and clinical implications.化学反射——生理学及临床意义
Acta Physiol Scand. 2003 Mar;177(3):377-84. doi: 10.1046/j.1365-201X.2003.01083.x.
5
The need for specificity in quantifying neurocirculatory vs. respiratory effects of eucapnic hypoxia and transient hyperoxia.需要明确区分低碳酸血症性缺氧和短暂性高氧对神经循环与呼吸的影响。
J Physiol. 2020 Nov;598(21):4803-4819. doi: 10.1113/JP280515. Epub 2020 Aug 25.
6
Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism.二肽基肽酶 4 抑制剂西他列汀通过胰高血糖素样肽 1 依赖机制保护高血压患者的血管内皮功能。
Hypertension. 2012 Sep;60(3):833-41. doi: 10.1161/HYPERTENSIONAHA.112.195115. Epub 2012 Aug 6.
7
Carotid chemoreceptor control of muscle sympathetic nerve activity in hypobaric hypoxia.低压缺氧时颈动脉化学感受器对肌肉交感神经活动的控制
Exp Physiol. 2018 Jan 1;103(1):77-89. doi: 10.1113/EP086493. Epub 2017 Nov 12.
8
Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input.颈动脉体功能和间歇性低氧时的通气反应。动脉化学感受器传入信息在脑干整合异常的证据。
J Cell Physiol. 2011 Aug;226(8):1961-9. doi: 10.1002/jcp.22528.
9
Peripheral chemoreflex activation induces expiratory but not inspiratory excitation of C1 pre-sympathetic neurones of rats.外周化学感受器的激活引起大鼠 C1 节前交感神经元的呼气性而非吸气性兴奋。
Acta Physiol (Oxf). 2022 Aug;235(4):e13853. doi: 10.1111/apha.13853. Epub 2022 Jun 28.
10
Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats.肾脏交感神经在 GLP-1（胰高血糖素样肽-1）受体激动剂 exendin-4 介导的饮食诱导肥胖大鼠利尿和利钠中的作用。
J Am Heart Assoc. 2021 Nov 2;10(21):e022542. doi: 10.1161/JAHA.121.022542. Epub 2021 Oct 29.
引用本文的文献
1
Liraglutide ameliorates TAC-induced cardiac hypertrophy and heart failure by upregulating expression level of ANP expression.利拉鲁肽通过上调心房钠尿肽（ANP）的表达水平来改善腹主动脉缩窄（TAC）诱导的心脏肥大和心力衰竭。
Heliyon. 2024 May 31;10(11):e32229. doi: 10.1016/j.heliyon.2024.e32229. eCollection 2024 Jun 15.
2
Commonalities and differences in carotid body dysfunction in hypertension and heart failure.高血压和心力衰竭中颈动脉体功能障碍的共性和差异。
J Physiol. 2023 Dec;601(24):5527-5551. doi: 10.1113/JP284114. Epub 2023 Sep 25.
本文引用的文献
1
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition.GLP1R 通过颈动脉体抑制来减轻高血糖引起的交感神经反应。
Circ Res. 2022 Mar 4;130(5):694-707. doi: 10.1161/CIRCRESAHA.121.319874. Epub 2022 Feb 1.
2
Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.颈动脉体化学感受器：生理学、病理学及对健康和疾病的影响。
Physiol Rev. 2021 Jul 1;101(3):1177-1235. doi: 10.1152/physrev.00039.2019. Epub 2021 Feb 11.
3
Functional interaction between Ghrelin and GLP-1 regulates feeding through the vagal afferent system.Ghrelin 和 GLP-1 之间的功能相互作用通过迷走传入系统调节进食。
Sci Rep. 2020 Oct 28;10(1):18415. doi: 10.1038/s41598-020-75621-5.
4
Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats.通过脑干儿茶酚胺神经元的中央胰高血糖素样肽-1 受体信号传导可抵抗自发性高血压大鼠的高血压。
Sci Rep. 2019 Sep 19;9(1):12986. doi: 10.1038/s41598-019-49364-x.
5
Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons.神经纤维中胰高血糖素样肽 1 受体 (GLP-1R) 在炎症性肠病中的表达及其对培养神经元的功能影响。
PLoS One. 2018 May 29;13(5):e0198024. doi: 10.1371/journal.pone.0198024. eCollection 2018.
6
KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure.KLF2 介导心力衰竭时化学感受反射敏感性增强、呼吸紊乱和自主神经调节障碍。
J Physiol. 2018 Aug;596(15):3171-3185. doi: 10.1113/JP273805. Epub 2017 Oct 11.
7
The structural factor of hypertension: large and small artery alterations.高血压的结构因素：大动脉和小动脉的改变。
Circ Res. 2015 Mar 13;116(6):1007-21. doi: 10.1161/CIRCRESAHA.116.303596.
8
Mechanisms of carotid body chemoreflex dysfunction during heart failure.心力衰竭期间颈动脉体化学反射功能障碍的机制。
Exp Physiol. 2015 Feb 1;100(2):124-9. doi: 10.1113/expphysiol.2014.079517. Epub 2015 Jan 15.
9
Glucose sensing by carotid body glomus cells: potential implications in disease.颈动脉体小球细胞的葡萄糖感应：疾病中的潜在意义。
Front Physiol. 2014 Oct 15;5:398. doi: 10.3389/fphys.2014.00398. eCollection 2014.
10
The autonomic nervous system and hypertension.自主神经系统与高血压。
Circ Res. 2014 May 23;114(11):1804-14. doi: 10.1161/CIRCRESAHA.114.302524.
Zotero 插件