Andreu-Sánchez Sergio, Ripoll-Cladellas Aida, Culinscaia Anna, Bulut Ozlem, Bourgonje Arno R, Netea Mihai G, Lansdorp Peter, Aubert Geraldine, Bonder Marc Jan, Franke Lude, Vogl Thomas, van der Wijst Monique G P, Melé Marta, Van Baarle Debbie, Fu Jingyuan, Zhernakova Alexandra
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
iScience. 2024 May 16;27(6):109981. doi: 10.1016/j.isci.2024.109981. eCollection 2024 Jun 21.
Encounters with pathogens and other molecules can imprint long-lasting effects on our immune system, influencing future physiological outcomes. Given the wide range of microbes to which humans are exposed, their collective impact on health is not fully understood. To explore relations between exposures and biological aging and inflammation, we profiled an antibody-binding repertoire against 2,815 microbial, viral, and environmental peptides in a population cohort of 1,443 participants. Utilizing antibody-binding as a proxy for past exposures, we investigated their impact on biological aging, cell composition, and inflammation. Immune response against cytomegalovirus (CMV), rhinovirus, and gut bacteria relates with telomere length. Single-cell expression measurements identified an effect of CMV infection on the transcriptional landscape of subpopulations of CD8 and CD4 T-cells. This examination of the relationship between microbial exposures and biological aging and inflammation highlights a role for chronic infections (CMV and Epstein-Barr virus) and common pathogens (rhinoviruses and adenovirus C).
接触病原体和其他分子会对我们的免疫系统产生持久影响，进而影响未来的生理结果。鉴于人类接触的微生物种类繁多，它们对健康的总体影响尚未完全明了。为了探究接触与生物衰老和炎症之间的关系，我们在一个由1443名参与者组成的人群队列中，对针对2815种微生物、病毒和环境肽的抗体结合谱进行了分析。利用抗体结合作为过去接触的替代指标，我们研究了它们对生物衰老、细胞组成和炎症的影响。针对巨细胞病毒（CMV）、鼻病毒和肠道细菌的免疫反应与端粒长度有关。单细胞表达测量确定了CMV感染对CD8和CD4 T细胞亚群转录图谱的影响。这项对微生物接触与生物衰老和炎症之间关系的研究突出了慢性感染（CMV和爱泼斯坦-巴尔病毒）和常见病原体（鼻病毒和腺病毒C）的作用。
