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莱姆病合并感染的诊断挑战:来自莱姆病与单纯疱疹病毒1型(HSV-1)混合感染的经验教训

Diagnostic Challenges of Lyme Co-infections: Lessons From a Lyme and Herpes Simplex Virus-1 (HSV-1) Cocktail.

作者信息

Bhatia Mannat K, Abdelbaky Mohamed, Lahoti Lokesh

机构信息

Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, Saint Peter's University Hospital, New Brunswick, USA.

出版信息

Cureus. 2024 May 13;16(5):e60213. doi: 10.7759/cureus.60213. eCollection 2024 May.

DOI:10.7759/cureus.60213
PMID:38868243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11167585/
Abstract

Lyme borreliosis (LB) is a complex tick-borne illness with diverse presentations. We report a case of LB meningitis with herpes simplex virus-1 (HSV-1) co-infection in a 55-year-old woman initially presenting with isolated facial nerve palsy. This case illustrates the multifaceted diagnostic challenges associated with Lyme co-infections. It emphasizes the need for thorough testing to identify all potential pathogens and the importance of differentiating between true co-infection and incidental HSV-1 reactivation. Understanding these complexities is crucial for guiding appropriate treatment decisions.

摘要

莱姆病(LB)是一种复杂的蜱传疾病,临床表现多样。我们报告了一例55岁女性莱姆病脑膜炎合并单纯疱疹病毒1型(HSV-1)感染的病例,该患者最初表现为孤立性面神经麻痹。该病例说明了莱姆病合并感染相关的多方面诊断挑战。它强调了进行全面检测以识别所有潜在病原体的必要性,以及区分真正的合并感染和偶然的HSV-1再激活的重要性。了解这些复杂性对于指导适当的治疗决策至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ed4/11167585/971e2f7ab3fc/cureus-0016-00000060213-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ed4/11167585/48646e31c931/cureus-0016-00000060213-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ed4/11167585/971e2f7ab3fc/cureus-0016-00000060213-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ed4/11167585/48646e31c931/cureus-0016-00000060213-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ed4/11167585/971e2f7ab3fc/cureus-0016-00000060213-i02.jpg

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本文引用的文献

1
Antibody Cross-Reactivity in Serodiagnosis of Lyme Disease.莱姆病血清学诊断中的抗体交叉反应性
Antibodies (Basel). 2023 Oct 5;12(4):63. doi: 10.3390/antib12040063.
2
Quantitative multiplexed strategies for human Lyme disease serological testing.定量多重策略用于人类莱姆病血清学检测。
Exp Biol Med (Maywood). 2021 Jun;246(12):1388-1399. doi: 10.1177/15353702211003496. Epub 2021 Apr 1.
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Estimating the Frequency of Lyme Disease Diagnoses, United States, 2010-2018.估计 2010-2018 年美国莱姆病诊断的频率。
Emerg Infect Dis. 2021 Feb;27(2):616-619. doi: 10.3201/eid2702.202731.
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Single Core Genome Sequencing for Detection of both Sensu Lato and Relapsing Fever Borrelia Species.单细胞基因组测序检测长角血蜱和回归热螺旋体种属。
Int J Environ Res Public Health. 2019 May 20;16(10):1779. doi: 10.3390/ijerph16101779.
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Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014.美国东南部莱姆病的地理扩张,2000-2014 年。
Open Forum Infect Dis. 2015 Sep 27;2(4):ofv143. doi: 10.1093/ofid/ofv143. eCollection 2015 Dec.
6
Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.莱姆病血清学检测在疾病低发地区的阳性预测值较低。
Clin Infect Dis. 2015 Nov 1;61(9):1374-80. doi: 10.1093/cid/civ584. Epub 2015 Jul 20.
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Diagnosis and treatment of Lyme arthritis.莱姆关节炎的诊断与治疗
Infect Dis Clin North Am. 2015 Jun;29(2):269-80. doi: 10.1016/j.idc.2015.02.004.
8
Lyme carditis.莱姆病性心脏炎
Infect Dis Clin North Am. 2015 Jun;29(2):255-68. doi: 10.1016/j.idc.2015.02.003.
9
The association of lyme disease with loss of sexual libido and the role of urinary bladder detrusor dysfunction.莱姆病与性欲丧失的关联,以及膀胱逼尿肌功能障碍的作用。
Int Neurourol J. 2014 Jun;18(2):95-7. doi: 10.5213/inj.2014.18.2.95. Epub 2014 Jun 26.
10
A young healthy male with syncope and complete heart block.一名年轻健康男性出现晕厥和完全性心脏阻滞。
Scott Med J. 2013 May;58(2):e13-7. doi: 10.1177/0036933013482661.