Nakajima Naomi, Tanaka Miho, Kanehara Akiko, Morishima Ryo, Kumakura Yousuke, Ohkouchi Noriko, Hamada Junko, Ogawa Tomoko, Tamune Hidetaka, Nakahara Mutsumi, Mori Shunsuke, Ichihashi Kayo, Jinde Seiichiro, Kano Yukiko, Sakamoto Ichiro, Tanaka Kyoko, Hirata Yoichiro, Ohashi Hirofumi, Shinohara Tokuko, Kasai Kiyoto
Department of Neuropsychiatry The University of Tokyo Hospital Tokyo Japan.
The Health Care Science Institute Tokyo Japan.
PCN Rep. 2023 Feb 13;2(1):e80. doi: 10.1002/pcn5.80. eCollection 2023 Mar.
The 22q11.2 deletion syndrome (22q11DS) is associated with a high prevalence of mental health comorbidities. However, not enough attention has been paid to the elevated prevalence of high trait anxiety that begins early in life and may be enduring. We sought to identify specific medical, welfare, or educational difficulties associated with high trait anxiety in 22q11DS.
A questionnaire-based survey was conducted for the parents of 22q11DS individuals ( = 125). First, a multiple regression analysis was conducted to confirm the hypothesis that high trait anxiety in individuals with 22q11DS would be associated with parents' psychological distress. This was based on 19 questionnaire options regarding what difficulties the parents currently face about their child's disease, characteristics, and traits. Next, we explored what challenges faced in medical, welfare, and educational services would be associated with the trait anxiety in their child.
The multiple regression analysis confirmed that the high trait anxiety was significantly associated with parental psychological distress ( = 0.265, = 0.018) among the 19 clinical/personal characteristics of 22q11DS. Furthermore, this characteristic was associated with various difficulties faced in the medical care, welfare, and education services, and the parent-child relationship.
To our knowledge, this is the first study to clarify quantitatively how the characteristic of high anxiety level in 22q11DS individuals is related to the caregivers' perceived difficulties in medical, welfare, and educational services. These results suggest the necessity of designing service structures informed of the fact that high trait anxiety is an important clinical feature of the syndrome.
22q11.2缺失综合征（22q11DS）与心理健康合并症的高患病率相关。然而，对于始于生命早期且可能持续存在的高特质焦虑患病率升高问题，尚未给予足够关注。我们试图确定与22q11DS中高特质焦虑相关的特定医疗、福利或教育困难。
对125名22q11DS个体的父母进行了问卷调查。首先，进行多元回归分析以证实22q11DS个体的高特质焦虑与父母心理困扰相关的假设。这是基于19个关于父母目前在孩子疾病、特征和特质方面面临哪些困难的问卷选项。接下来，我们探讨了医疗、福利和教育服务中面临的哪些挑战与孩子的特质焦虑相关。
多元回归分析证实，在22q11DS的19项临床/个人特征中，高特质焦虑与父母心理困扰显著相关（β = 0.265，p = 0.018）。此外，这一特征与医疗、福利和教育服务以及亲子关系中面临的各种困难相关。
据我们所知，这是第一项定量阐明22q11DS个体高焦虑水平特征如何与照顾者在医疗、福利和教育服务中感知到的困难相关的研究。这些结果表明，有必要设计服务结构，充分认识到高特质焦虑是该综合征的一个重要临床特征。
