Yamaguchi Yusei, Takagi Shunsuke, Takahashi Hidehiko, Sugihara Genichi
Department of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School Tokyo Japan.
Sleep Research Institute Waseda University Tokyo Japan.
PCN Rep. 2024 Jan 10;3(1):e163. doi: 10.1002/pcn5.163. eCollection 2024 Mar.
We present a case report on the efficacy of the short-term application of vortioxetine in managing winter depression in patients with seasonal bipolar disorder (BP). Standard treatment strategies for BP may not adequately address seasonal depressive symptoms during winter in patients with seasonal BP patterns. Depressive symptoms during winter may be linked to seasonal changes in serotonin transporter binding, such as a decrease in synaptic serotonin levels, necessitating alternative approaches. Although antidepressants, including vortioxetine, are effective in treating seasonal monopolar depression, their efficacy and safety in treating depression in patients with seasonal BP patterns remain unclear.
This case report focuses on a 44-year-old male patient diagnosed with seasonal BP who had recurrent depressive episodes, specifically during winter. Notably, the patient had a significant decrease in recurrent episodes after short-term seasonal vortioxetine use without inducing mania or rapid cycling.
Our study highlights the potential effectiveness of a seasonal, short-term treatment strategy with antidepressants, including vortioxetine, for winter depression in individuals with BP.
我们报告一例关于伏硫西汀短期应用治疗季节性双相情感障碍（BP）患者冬季抑郁疗效的病例。BP的标准治疗策略可能无法充分解决季节性BP模式患者冬季的季节性抑郁症状。冬季的抑郁症状可能与血清素转运体结合的季节性变化有关，比如突触血清素水平降低，因此需要采用替代方法。尽管包括伏硫西汀在内的抗抑郁药在治疗季节性单相抑郁方面有效，但其治疗季节性BP模式患者抑郁的疗效和安全性仍不明确。
本病例报告聚焦于一名44岁被诊断为季节性BP的男性患者，该患者有复发性抑郁发作，尤其是在冬季。值得注意的是，该患者在短期季节性使用伏硫西汀后复发次数显著减少，且未诱发躁狂或快速循环发作。
我们的研究强调了包括伏硫西汀在内的抗抑郁药进行季节性短期治疗策略对BP患者冬季抑郁的潜在有效性。
