Sharma Vishwas, Kumar Dinesh, Kumar Shravan, Singh Harpreet, Sharma Naveen, Gupta Sanjay
Division of Cytopathology ICMR-National Institute of Cancer Prevention and Research Noida Uttar Pradesh India.
WHO FCTC Global Knowledge Hub on Smokeless Tobacco ICMR- National Institute of Cancer Prevention and Research Noida Uttar Pradesh India.
Imeta. 2022 Aug 4;1(3):e44. doi: 10.1002/imt2.44. eCollection 2022 Sep.
This study identified a total of 28 genetic loci (comprising 31 genes), which were found to be altered in oral cancer patients having a habit of tobacco smoking. Three loci, that is, 17p13.1 (), 9p21.3 (), and 9q34.3 () were found to be modified and common in three records whereas one locus, that is, 3q26.32 () was found to be modified and common in two records. This study suggests that oral cancer patients should be categorized into different subgroups based on (i) genetic signatures, and (ii) smoking status, then the treatment strategies for each group should be precisely defined.
本研究共鉴定出28个基因位点（包含31个基因），发现这些位点在有吸烟习惯的口腔癌患者中发生了改变。三个位点，即17p13.1（）、9p21.3（）和9q34.3（）在三条记录中被发现发生了改变且具有共性，而一个位点，即3q26.32（）在两条记录中被发现发生了改变且具有共性。本研究表明，应根据（i）基因特征和（ii）吸烟状况将口腔癌患者分为不同亚组，然后应精确确定每组的治疗策略。
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