Ikram S, Mirtorabi N, Ali D, Aain H, Naumann D N, Dilworth M
University Hospitals Birmingham NHS Foundation Trust, UK.
Ann R Coll Surg Engl. 2025 Feb;107(2):146-150. doi: 10.1308/rcsann.2023.0040. Epub 2024 Jun 13.
Timely preoperative computed tomography (CT) scans are important for patients requiring emergency laparotomy. United Kingdom guidelines state that a CT scan should be reported within 1h for 'critical' patients (will alter management at the time) and within 12h for 'urgent' patients (will alter management but not necessarily that day).
An observational study included patients who were added to the National Emergency Laparotomy Audit (NELA) at a National Health Service trust from 2014 to 2021. The association of compliance with timings guidance and mortality was investigated. Multivariable logistic regression was used to determine the odds ratio of adherence to guidelines according to age, gender, night time admission, American Society of Anesthesiology (ASA) score, NELA mortality risk and category of scan. Further models determined the influence of adherence to guidelines on mortality, also adjusted for these variables.
There were 1,299 patients (48% 'critical' and 52% 'urgent' CT scans). Only 360/1,299 (28%) of scans were undertaken with adherence to the timing guidelines. Critical scans were less likely to adhere to guidelines. Although univariable analysis suggested that adherence to guidelines was associated with reduced mortality, this was not the case in the multivariable model: only age, ASA and NELA mortality risk remained significantly associated with mortality.
A minority of patients met the recommended preoperative CT report timings, and this was less likely for scans designated 'critical'. This did not appear to affect mortality when adjusted for key variables of risk. This illustrates the phenomenon of guideline adherence appearing to affect patient outcomes as a product of selection bias rather than causality.
对于需要急诊剖腹手术的患者,及时进行术前计算机断层扫描(CT)很重要。英国指南规定,对于“危急”患者(当时会改变治疗方案),CT扫描报告应在1小时内完成;对于“紧急”患者(会改变治疗方案,但不一定在当天),应在12小时内完成。
一项观察性研究纳入了2014年至2021年在一家国民医疗服务信托机构被纳入国家急诊剖腹手术审计(NELA)的患者。研究了遵守时间指导与死亡率之间的关联。采用多变量逻辑回归来确定根据年龄、性别、夜间入院、美国麻醉医师协会(ASA)评分、NELA死亡风险和扫描类别遵守指南的比值比。进一步的模型确定了遵守指南对死亡率的影响,并对这些变量进行了调整。
共有1299例患者(48%为“危急”CT扫描,52%为“紧急”CT扫描)。只有360/1299(28%)的扫描是按照时间指南进行的。危急扫描更不可能遵守指南。尽管单变量分析表明遵守指南与降低死亡率相关,但在多变量模型中并非如此:只有年龄、ASA评分和NELA死亡风险仍与死亡率显著相关。
少数患者达到了推荐的术前CT报告时间,对于指定为“危急”的扫描,这种可能性更小。在对关键风险变量进行调整后,这似乎并未影响死亡率。这说明了指南遵守似乎影响患者结局是选择偏倚而非因果关系的产物这一现象。