Department of Ultrasound, Institute of Ultrasound Teaching and Research, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Department of Radiology, Institute of Radiation and Therapy, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Nanoscale. 2024 Jul 4;16(26):12287-12308. doi: 10.1039/d4nr02026j.
The rapid growth of research on enzyme-mimetic catalysts (Enz-Cats) is expected to promote further advances in nanomedicine for biological detection, diagnosis and treatment of disease, especially tumors. ROS-based nanomedicines present fascinating potential in antitumor therapy owing to the rapid development of nanotechnology. In this review, we focus on the applications of Enz-Cats based on ROS in antitumor therapy. Firstly, the definition and category of ROS are introduced, and the key factors enhancing ROS levels are carefully elucidated. Then, the rationally engineered Enz-Cats different synthetic approaches with high ROS-producing efficiencies are comprehensively discussed. Subsequently, oncotherapy application of Enz-Cats is comprehensively discussed, which integrates diverse synergistic treatment modalities and exhibits high efficiency in ROS generation. Finally, the challenges and future research direction of this field are presented. This review is dedicated to unraveling the enigmas surrounding the interplay of nanomedicine and organisms.
酶模拟催化剂（Enz-Cats）的研究迅速发展，有望推动纳米医学在生物检测、疾病诊断和治疗方面的进一步发展，尤其是在肿瘤方面。基于活性氧（ROS）的纳米医学由于纳米技术的快速发展，在抗肿瘤治疗方面具有诱人的潜力。在本文中，我们重点关注基于 ROS 的 Enz-Cats 在抗肿瘤治疗中的应用。首先，介绍了 ROS 的定义和分类，并详细阐明了提高 ROS 水平的关键因素。然后，全面讨论了具有高 ROS 产生效率的合理设计的 Enz-Cats 的不同合成方法。随后，全面讨论了 Enz-Cats 的肿瘤治疗应用，它整合了多种协同治疗模式，在 ROS 产生方面具有高效性。最后，提出了该领域的挑战和未来研究方向。本文旨在揭示纳米医学与生物体相互作用的奥秘。
