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TLR 高速公路交通。

Traffic on the TLR expressway.

机构信息

Department of Pediatrics and Center for Genetic Errors of Immunity, Columbia University Medical Center, New York, NY, USA.

出版信息

J Exp Med. 2024 Aug 5;221(8). doi: 10.1084/jem.20240841. Epub 2024 Jun 13.

DOI:10.1084/jem.20240841

PMID:38869499

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11176255/

Abstract

Genetic variation in UNC93B1, a key component in TLR trafficking, can lead to autoinflammation caused by increased TLR activity. Analysis of seven patient variants combined with a comprehensive alanine screen revealed that different regions of UNC93B1 selectively regulate different TLRs (Rael et al. https://doi.org/10.1084/jem.20232005; David et al. https://doi.org/10.1084/jem.20232066).

摘要

UNC93B1 中的遗传变异是 TLR 运输的关键组成部分，可导致 TLR 活性增加引起的自身炎症。对七个患者变异体的分析与全面的丙氨酸筛选相结合，表明 UNC93B1 的不同区域选择性地调节不同的 TLR（Rael 等人，https://doi.org/10.1084/jem.20232005；David 等人，https://doi.org/10.1084/jem.20232066）。