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由肺炎克雷伯菌序列型 ST660 引起的伴有多个局部感染性败血症的菌血症。

Bacteraemia associated with multiple septic localizations caused by Klebsiella pneumoniae sequence type ST660.

机构信息

Bacteriology department, CHU Bordeaux, Bordeaux, F-33000, France.

Bordeaux Institute of Oncology, BRIC U1312, INSERM, University of Bordeaux, Bordeaux, F-33000, France.

出版信息

Eur J Clin Microbiol Infect Dis. 2024 Aug;43(8):1655-1659. doi: 10.1007/s10096-024-04870-3. Epub 2024 Jun 13.

DOI:10.1007/s10096-024-04870-3
PMID:38869685
Abstract

We report a case of Klebsiella pneumoniae bacteraemia in an 80-year-old man in France with no history of travel to Asia, complicated by endogenous endophthalmitis, multiple cerebral microbleeds and hepatic microabscesses, associated with a Bentall endocarditis. Hypervirulence pathotype was suggested based on clinical picture, bacterial isolate genomic sequence and hypermucoidy. Interestingly, the isolate had the non-K1/K2-capsular serotype locus KL113-like, carried a KpVP-1-like virulence plasmid, and belonged to the emerging sublineage SL660 (comprising the sequence type ST660).

摘要

我们报告了一例发生在法国的 80 岁老年男性的肺炎克雷伯菌菌血症病例，该患者无亚洲旅行史，并发内源性眼内炎、多发脑微出血和肝微脓肿，合并本-戈尔登心脏病。基于临床表现、细菌分离株基因组序列和高黏液性，提示该菌为高毒力型。有趣的是，该分离株具有非 K1/K2 荚膜血清型 KL113 样结构，携带 KpVP-1 样毒力质粒，属于新兴亚谱系 SL660（包括序列类型 ST660）。

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Eur J Clin Microbiol Infect Dis. 2024 Aug;43(8):1655-1659. doi: 10.1007/s10096-024-04870-3. Epub 2024 Jun 13.
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