Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, United Kingdom.
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, United Kingdom.
Cancer Discov. 2024 Jul 1;14(7):1154-1160. doi: 10.1158/2159-8290.CD-24-0128.
Environmental carcinogens increase cancer incidence via both mutagenic and non-mutagenic mechanisms. There are over 500 known or suspected carcinogens classified by the International Agency for Research on Cancer. Sequencing of both cancerous and histologically non-cancerous tissue has been instrumental in improving our understanding of how environmental carcinogens cause cancer. Understanding how and defining which environmental or lifestyle exposures drive cancer will support cancer prevention. Recent research is revisiting the mechanisms of early tumorigenesis, paving the way for an era of molecular cancer prevention. Significance: Recent data have improved our understanding of how carcinogens cause cancer, which may reveal novel opportunities for molecular cancer prevention.
环境致癌物通过致突变和非致突变机制增加癌症发病率。国际癌症研究机构已对超过 500 种已知或疑似致癌物进行了分类。对癌症组织和组织学上非癌症组织的测序有助于我们更好地了解环境致癌物如何引发癌症。了解环境或生活方式暴露如何驱动癌症以及定义哪些因素会导致癌症，将有助于癌症预防。最近的研究重新审视了早期肿瘤发生的机制，为分子癌症预防时代铺平了道路。意义：最近的数据提高了我们对致癌物引发癌症的机制的理解，这可能为分子癌症预防带来新的机会。
