Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Leg Med (Tokyo). 2024 Sep;70:102469. doi: 10.1016/j.legalmed.2024.102469. Epub 2024 Jun 6.
Monoamine oxidase A (MAOA) catalyzes oxidative deamination of catecholamines. A functional variable number tandem repeat (VNTR) polymorphism in the promoter region of the MAOA gene has been previously reported. In the present study, we measured serum adrenaline (Adr), noradrenaline (Nad), and dopamine (DA) levels in 90 male and 34 female Japanese autopsy cases in which amphetamines or psychotropic drugs were not detected.We examined the frequencies of MAOA-uVNTR alleles in these cases and investigated the effects of the MAOA-uVNTR polymorphism on serum Adr, Nad, and DA levels. Evaluation indicated no significant association between MAOA-uVNTR polymorphism and serum Adr, Nad, or DA levels in males, although a significant association between MAOA-uVNTR polymorphism and serum Adr and DA levels were observed in females. Females with the 3/3 genotype had higher serum Adr and DA levels than those with a 4-repeat allele (3/4 and 4/4 genotypes) (p = 0.048 and 0.020, respectively). There was no significant association between MAOA-uVNTR polymorphism and serum Nad levels in females. The present study indicates that MAOA-uVNTR polymorphism influences serum Adr and DA levels only in females.
单胺氧化酶 A（MAOA）催化儿茶酚胺的氧化脱氨。先前已经报道了 MAOA 基因启动子区域的功能可变数目串联重复（VNTR）多态性。在本研究中，我们测量了 90 名男性和 34 名女性日本尸检案例中的血清肾上腺素（Adr）、去甲肾上腺素（Nad）和多巴胺（DA）水平，这些案例中未检测到安非他命或精神药物。我们检查了这些案例中 MAOA-uVNTR 等位基因的频率，并研究了 MAOA-uVNTR 多态性对血清 Adr、Nad 和 DA 水平的影响。评估表明，男性 MAOA-uVNTR 多态性与血清 Adr、Nad 或 DA 水平之间没有显著关联，尽管在女性中观察到 MAOA-uVNTR 多态性与血清 Adr 和 DA 水平之间存在显著关联。与 4 个重复等位基因（3/4 和 4/4 基因型）相比，3/3 基因型的女性血清 Adr 和 DA 水平更高（p=0.048 和 0.020）。女性 MAOA-uVNTR 多态性与血清 Nad 水平之间没有显著关联。本研究表明，MAOA-uVNTR 多态性仅在女性中影响血清 Adr 和 DA 水平。
