State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai 200001, China.
State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai 200001, China.
Cell Host Microbe. 2024 Jun 12;32(6):783-785. doi: 10.1016/j.chom.2024.05.007.
Previous studies have explored the role of the gut microbiota in regulating endobiotic homeostasis, but the precise mechanisms remain unclear. In this issue of Cell Host & Microbe, Simpson et al. identified two predominant subtypes of gut microbial β-Glucuronidase (gmGUS) that can reactivate hormones and neurotransmitters to regulate endobiotic homeostasis.
先前的研究已经探讨了肠道微生物群在调节内源性稳态中的作用，但确切的机制仍不清楚。在本期《细胞宿主与微生物》杂志中，辛普森等人鉴定出两种主要的肠道微生物β-葡萄糖醛酸酶（gmGUS）亚型，它们可以使激素和神经递质重新激活，从而调节内源性稳态。
