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在移植中心,造血细胞移植的机会仍然存在差异。

Disparities in access to hematopoietic cell transplant persist at a transplant center.

机构信息

Division of Pediatric Hematology, Oncology, and Blood & Marrow Transplantation, Pediatric Institute, Cleveland Clinic, Cleveland, OH, USA.

Center for Populations Health Research, Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.

出版信息

Bone Marrow Transplant. 2024 Sep;59(9):1258-1264. doi: 10.1038/s41409-024-02327-x. Epub 2024 Jun 13.

DOI:10.1038/s41409-024-02327-x
PMID:38871963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11368813/
Abstract

Disparities in access to hematopoietic cell transplant (HCT) are well established. Prior studies have identified barriers, such as referral and travel to an HCT center, that occur before consultation. Whether differences in access persist after evaluation at an HCT center remains unknown. The psychosocial assessment for transplant eligibility may impede access to transplant after evaluation. We performed a single-center retrospective review of 1102 patients who underwent HCT consultation. We examined the association between race/ethnicity (defined as Hispanic, non-Hispanic Black, non-Hispanic White, and Other) and socioeconomic status (defined by zip code median household income quartiles and insurance type) with receipt of HCT and Psychosocial Assessment of Candidates for Transplantation (PACT) scores. Race/ethnicity was associated with receipt of HCT (p = 0.02) with non-Hispanic Whites comprising a higher percentage of HCT recipients than non-recipients. Those living in higher income quartiles and non-publicly insured were more likely to receive HCT (p = 0.02 and p < 0.001, respectively). PACT scores were strongly associated with income quartiles (p < 0.001) but not race/ethnicity or insurance type. Race/ethnicity and socioeconomic status impact receipt of HCT among patients evaluated at an HCT center. Further investigation as to whether the psychosocial eligibility evaluation limits access to HCT in vulnerable populations is warranted.

摘要

造血细胞移植 (HCT) 的机会存在差异,这是众所周知的。先前的研究已经确定了一些障碍,例如在咨询之前转诊和前往 HCT 中心,这些障碍发生在咨询之前。在 HCT 中心进行评估后,获得 HCT 的机会是否存在差异仍不得而知。移植资格的社会心理评估可能会阻碍评估后进行移植。我们对 1102 名接受 HCT 咨询的患者进行了单中心回顾性研究。我们研究了种族/民族(定义为西班牙裔、非西班牙裔黑人、非西班牙裔白人、其他)和社会经济地位(定义为邮政编码家庭收入四分位数和保险类型)与接受 HCT 和候选者移植的社会心理评估 (PACT) 评分之间的关系。种族/民族与接受 HCT 有关(p=0.02),非西班牙裔白人接受 HCT 的比例高于未接受者。居住在收入较高四分位数和非公共保险的人更有可能接受 HCT(p=0.02 和 p<0.001)。PACT 评分与收入四分位数密切相关(p<0.001),但与种族/民族或保险类型无关。种族/民族和社会经济地位影响 HCT 中心评估的患者接受 HCT 的机会。有必要进一步研究社会心理资格评估是否限制了弱势群体获得 HCT 的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acfb/11368813/f2760c0dfbc7/41409_2024_2327_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acfb/11368813/f2760c0dfbc7/41409_2024_2327_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acfb/11368813/f2760c0dfbc7/41409_2024_2327_Fig1_HTML.jpg

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The ASTCT-NMDP ACCESS Initiative: A Collaboration to Address and Sustain Equal Outcomes for All across the Hematopoietic Cell Transplantation and Cellular Therapy Ecosystem.ASTCT-NMDP ACCESS 倡议:为了在造血细胞移植和细胞治疗生态系统中实现所有参与者的平等结果而进行的合作。
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Blood Adv. 2019 Oct 22;3(20):2986-2994. doi: 10.1182/bloodadvances.2019000308.
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Psychosocial Assessment of Candidates for Transplantation scale (PACT) and survival after allogeneic hematopoietic stem cell transplantation.移植候选人的心理社会评估量表(PACT)与异基因造血干细胞移植后的生存。
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