Davies J, Francis A A, Oakes D J, Sheardown M J, Watkins J C
Neuropharmacology. 1985 Feb;24(2):177-80. doi: 10.1016/0028-3908(85)90178-9.
In dorsal horn neurones of the cat spinal cord iontophoretically administered (+/-)-beta-p-chlorophenylglutamate (chlorpheg) markedly enhanced the excitatory responses induced by L-homocysteate, L-homocysteine sulphinate, S-sulpho L-cysteine, L-cysteate and quisqualate, while responses to NMDA, kainate, L-glutamate, L-aspartate and L-cysteine sulphinate were generally unaffected. Preliminary data obtained on frog spinal cord in vitro supports the possibility that such selective potentiation may be due to differential inhibition by chlorpheg of amino acid uptake. No potentiating effects of chlorpheg were observed on spinal synaptic excitation.
在猫脊髓背角神经元中，经离子导入法给予（±）-β-对氯苯基谷氨酸（氯苯庚胺）可显著增强由L-同型半胱氨酸、L-同型半胱氨酸亚磺酸盐、S-磺基-L-半胱氨酸、L-半胱氨酸盐和喹啉酸诱导的兴奋性反应，而对NMDA、 kainate、L-谷氨酸、L-天冬氨酸和L-半胱氨酸亚磺酸盐的反应通常不受影响。在体外青蛙脊髓上获得的初步数据支持了这样一种可能性，即这种选择性增强可能是由于氯苯庚胺对氨基酸摄取的差异性抑制所致。未观察到氯苯庚胺对脊髓突触兴奋有增强作用。
