Hu Yulin, Xu Baoqi, Li Wei, Liang Lin, Fei Fan, Lin Quankui
National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
J Nanobiotechnology. 2024 Jun 13;22(1):332. doi: 10.1186/s12951-024-02564-8.
The human cannot detect light with a wavelength exceeding 700 nm, primarily due to limitations in the physiological structure of the human eye. However, in certain specific scenarios, the ability to detect near-infrared (NIR) light proves to be extremely valuable. To attain this desired capability, NIR up conversion nanoparticles (UCNPs) were prepared and doped in the optical lens materials, aiming to obtain a NIR light "visible" optical lens. It is demonstrated that the doping of UCNPs in the optical lens materials does not significantly impact on their mechanical properties, optical properties, surface properties and it exhibits excellent biocompatibility in cell and animal experiments. More importantly, the UCNPs doping can convert NIR light into visible light within the material effectively and stably. The eyes can "see" the NIR light after wearing such UCNPs doped optical lens. Such NIR light visible optical lens could have great potential in actual applications.
人类无法检测波长超过700纳米的光，这主要是由于人眼生理结构的限制。然而，在某些特定场景中，检测近红外（NIR）光的能力被证明极具价值。为了获得这种所需的能力，制备了近红外上转换纳米颗粒（UCNPs）并将其掺杂到光学透镜材料中，旨在获得一种能使近红外光“可见”的光学透镜。结果表明，在光学透镜材料中掺杂UCNPs对其机械性能、光学性能、表面性能没有显著影响，并且在细胞和动物实验中表现出优异的生物相容性。更重要的是，UCNPs掺杂能够在材料内部有效地、稳定地将近红外光转换为可见光。佩戴这种掺杂UCNPs的光学透镜后，眼睛就能“看到”近红外光。这种近红外光可见光学透镜在实际应用中可能具有巨大潜力。
