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Wnt/β-catenin 信号通路在非小细胞肺癌发生发展及治疗抵抗中的作用

Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer.

机构信息

Department of Genetic and Developmental Biology, School of Medicine, Southeast University, Nanjing, 210003, China.

High-Throughput Analytics, Analytical Research and Development, Merck & Co. Inc., Rahway, NJ, USA.

出版信息

J Transl Med. 2024 Jun 13;22(1):565. doi: 10.1186/s12967-024-05380-8.

DOI:10.1186/s12967-024-05380-8
PMID:38872189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11170811/
Abstract

Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote or inhibit signaling by acting on Wnt proteins, receptors, signal transducers and transcriptional effectors. The identification of these regulators and their underlying molecular mechanisms provides important implications for how to target this pathway therapeutically. In this review, we summarize recent studies of Wnt regulators in the development and therapeutic response of NSCLC.

摘要

Wnt/β-catenin 信号通路是影响非小细胞肺癌（NSCLC）发生发展和治疗反应的关键通路。近年来，许多 Wnt 调控因子，包括蛋白质、miRNA、lncRNA 和 circRNA，被发现通过作用于 Wnt 蛋白、受体、信号转导子和转录效应子来促进或抑制信号转导。这些调控因子及其潜在的分子机制的鉴定为如何靶向该通路进行治疗提供了重要的启示。在这篇综述中，我们总结了 Wnt 调控因子在 NSCLC 发生发展和治疗反应中的最新研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8d/11170811/cc4f58fbbd85/12967_2024_5380_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8d/11170811/000f3d1d761a/12967_2024_5380_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8d/11170811/cc4f58fbbd85/12967_2024_5380_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8d/11170811/000f3d1d761a/12967_2024_5380_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8d/11170811/cc4f58fbbd85/12967_2024_5380_Fig2_HTML.jpg

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Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer.

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[9]
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[10]
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本文引用的文献

[1]
Non-Small Cell Lung Cancer, Version 4.2024, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw. 2024-5

[2]
Modulating β-catenin homeostasis for cancer therapy.

Trends Cancer. 2024-6

[3]
LncRNA AL139294.1 can be transported by extracellular vesicles to promote the oncogenic behaviour of recipient cells through activation of the Wnt and NF-κB2 pathways in non-small-cell lung cancer.

J Exp Clin Cancer Res. 2024-1-16

[4]
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.

Nat Commun. 2023-10-5

[5]
Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating β-catenin.

Cancer Cell Int. 2023-9-19

[6]
ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/β-catenin pathway.

Aging (Albany NY). 2023-9-18

[7]
RRM2‑mediated Wnt/β‑catenin signaling pathway activation in lung adenocarcinoma: A potential prognostic biomarker.

Oncol Lett. 2023-8-10

[8]
CircZSWIM4 facilitates tumor development in lung adenocarcinoma by targeting miR-370-3p and miR-873-5p to regulate the axis of FOXM1/β-catenin.

Cell Mol Biol (Noisy-le-grand). 2023-6-30

[9]
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications.

Signal Transduct Target Ther. 2023-8-11

[10]
The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition.

Elife. 2023-8-7

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